Exacerbation of wood smoke-induced acute lung injury by mechanical ventilation using moderately high tidal volume in mice

You Lan Yang, Gau Jun Tang, Yuh Lin Wu, Huey Wen Yien, Tzong Shyuan Lee, Yu Ru Kou

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)

摘要

We investigated the effects of mechanical ventilation with a moderately high tidal volume (VT) on acute lung injury (ALI) induced by wood smoke inhalation in anesthetized mice. Animals received challenges of air, 30 breaths of smoke (30SM) or 60 breaths of smoke (60SM) and were then ventilated with a VT of 10 ml/kg (10VT) or 16 ml/kg (16VT). After 4-h mechanical ventilation, the bronchoalveolar-capillary permeability, pulmonary infiltration of inflammatory cells, total lung injury score and pulmonary expressions of interleukin-1β and macrophage inflammatory protein-2 mRNA and proteins in the 30SM + 16VT and 60SM + 16VT groups were greater than those in the 30SM + 10VT and 60SM + 10VT groups, respectively. Additionally, the wet/dry weight ratio of lung tissues and lung epithelial cell apoptosis in the 60SM + 16VT group were greater than those in the 60SM + 10VT group. These differences between the 16VT and 10VT groups were not seen in animals with air challenge. Thus, mechanical ventilation with a moderately high VT in mice exacerbates ALI induced by wood smoke inhalation.

原文英語
頁(從 - 到)99-108
頁數10
期刊Respiratory Physiology and Neurobiology
160
發行號1
DOIs
出版狀態已發佈 - 一月 1 2008
對外發佈Yes

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

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