Ex-vivo multiphoton analysis of rabbit corneal wound healing following photorefractive keratectomy

Tsung-Jen Wang, Wen Lo, Chen Yuan Dong, Fung Rong Hu

研究成果: 書貢獻/報告類型會議貢獻

摘要

The aim of this study is to assess the application of multiphoton auto fluorescence and second harmonic generation (SHG) microscopy for investigating corneal wound healing after high myopic (-10.OD) photorefractive keratectomy (PRK) procedures on the rabbit eyes. The effect of PRK on the morphology and distribution of keratocytes were investigated using multiphoton excited autofluorescence imaging, while the effect of PRK on the arrangement of collagen fibers was monitored by second-harmonic generation imaging. Without histological processing, multiphoton microscopy is able to characterize corneal damage and wound healing from PRK. Our results show that this technique has potential application in the clinical evaluation of corneal damage due to refractive surgery, and may be used to study the unwanted side effects of these procedures.
原文英語
主出版物標題Progress in Biomedical Optics and Imaging - Proceedings of SPIE
6844
DOIs
出版狀態已發佈 - 2008
事件Ophthalmic Technologies XVIII - San Jose, CA, 美国
持續時間: 一月 19 2008一月 21 2008

其他

其他Ophthalmic Technologies XVIII
國家美国
城市San Jose, CA
期間1/19/081/21/08

ASJC Scopus subject areas

  • Engineering(all)

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  • 引用此

    Wang, T-J., Lo, W., Dong, C. Y., & Hu, F. R. (2008). Ex-vivo multiphoton analysis of rabbit corneal wound healing following photorefractive keratectomy. 於 Progress in Biomedical Optics and Imaging - Proceedings of SPIE (卷 6844). [684414] https://doi.org/10.1117/12.762212