Evolutional change of karyotype with t(8;9)(p22;p24) and HLA-DR immunophenotype in relapsed acute myeloid leukemia

Kuan Po Huang, Andrew J. Chase, Nicholas C.P. Cross, Andrea Reiter, Tzu Ying Li, Tso Fu Wang, Sung Chao Chu, Xuan Yin Lu, Chi Cheng Li, Ruey Ho Kao

研究成果: 雜誌貢獻文章

9 引文 (Scopus)

摘要

The rare recurrent translocation of (8;9)(p22;p24) with PCM1-JAK2 fusion was recently characterized in diverse hematological malignancies. Most of them are atypical chronic myeloid leukemia (CML) or other myeloproliferative disorders (MPD), and are predominantly in the male. We report a female patient with acute myeloid leukemia (AML) initially presenting with normal karyotype and negative HLA-DR expression who achieved complete remission after standard chemotherapy. The disease relapsed 7 months later with cytogenetic change of t(8;9)(p22;p24). Flow cytometry analysis showed evolutional change of immunophenotype from negative to positive HLA-DR expression and fluorescence in situ hybridization (FISH) analysis demonstrated a PCM1-JAK2 fusion gene. We speculate that the cytogenetic change of t(8;9)(p22;p24) may induce HLA-DR immunophenotypic switch and a coordination of the two evolutional changes may play a role in leukemic cell progression.
原文英語
頁(從 - 到)197-201
頁數5
期刊International Journal of Hematology
88
發行號2
DOIs
出版狀態已發佈 - 九月 1 2008
對外發佈Yes

指紋

HLA-DR Antigens
Karyotype
Acute Myeloid Leukemia
Cytogenetics
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Myeloproliferative Disorders
Gene Fusion
Hematologic Neoplasms
Fluorescence In Situ Hybridization
Flow Cytometry
Drug Therapy

ASJC Scopus subject areas

  • Hematology

引用此文

Evolutional change of karyotype with t(8;9)(p22;p24) and HLA-DR immunophenotype in relapsed acute myeloid leukemia. / Huang, Kuan Po; Chase, Andrew J.; Cross, Nicholas C.P.; Reiter, Andrea; Li, Tzu Ying; Wang, Tso Fu; Chu, Sung Chao; Lu, Xuan Yin; Li, Chi Cheng; Kao, Ruey Ho.

於: International Journal of Hematology, 卷 88, 編號 2, 01.09.2008, p. 197-201.

研究成果: 雜誌貢獻文章

Huang, Kuan Po ; Chase, Andrew J. ; Cross, Nicholas C.P. ; Reiter, Andrea ; Li, Tzu Ying ; Wang, Tso Fu ; Chu, Sung Chao ; Lu, Xuan Yin ; Li, Chi Cheng ; Kao, Ruey Ho. / Evolutional change of karyotype with t(8;9)(p22;p24) and HLA-DR immunophenotype in relapsed acute myeloid leukemia. 於: International Journal of Hematology. 2008 ; 卷 88, 編號 2. 頁 197-201.
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abstract = "The rare recurrent translocation of (8;9)(p22;p24) with PCM1-JAK2 fusion was recently characterized in diverse hematological malignancies. Most of them are atypical chronic myeloid leukemia (CML) or other myeloproliferative disorders (MPD), and are predominantly in the male. We report a female patient with acute myeloid leukemia (AML) initially presenting with normal karyotype and negative HLA-DR expression who achieved complete remission after standard chemotherapy. The disease relapsed 7 months later with cytogenetic change of t(8;9)(p22;p24). Flow cytometry analysis showed evolutional change of immunophenotype from negative to positive HLA-DR expression and fluorescence in situ hybridization (FISH) analysis demonstrated a PCM1-JAK2 fusion gene. We speculate that the cytogenetic change of t(8;9)(p22;p24) may induce HLA-DR immunophenotypic switch and a coordination of the two evolutional changes may play a role in leukemic cell progression.",
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AU - Reiter, Andrea

AU - Li, Tzu Ying

AU - Wang, Tso Fu

AU - Chu, Sung Chao

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AU - Kao, Ruey Ho

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