Evolutional change in epicardial fat and its correlation with myocardial diffuse fibrosis in heart failure patients

Cho Kai Wu, Hao Yuan Tsai, Mao Yuan M. Su, Yi Fan Wu, Juey Jen Hwang, Jiunn Lee Lin, Lian Yu Lin, Jien Jiun Chen

研究成果: 雜誌貢獻文章

20 引文 (Scopus)

摘要

Objectives The aim of this study was to characterize the characteristics of epicardial fat (EAT) in different stage heart failure (HF) patients and its relationship between cardiac fibrosis. Background EAT is visceral adipose tissue that possesses inflammatory properties. Inflammation and obesity are associated with cardiac fibrosis, but the relationship between cardiac fibrosis and EAT is unknown. Methods EAT volume was measured using cardiac magnetic resonance imaging (CMR) in 180 subjects: 58 patients with systolic HF, 63 patients with HF and preserved ejection fraction, and 59 patients without HF. CMR derived myocardial extracellular volume (ECV) was used for fibrosis quantification. Results Patients with systolic HF had significantly more EAT compared with patients with HF and preserved ejection fraction or the control group (patients without HF) (indexed EAT volume [mL/m2], 27.0 [22.7–31.6] vs 25.6 [21.4–31.2] and 24.2 [21.0–27.6], P <.05). The adjusted EAT amount was associated with ECV completely independent of age, hypertension, diabetes, etiology of HF, left ventricular ejection fraction, CMR–late gadolinium enhancement (LGE), left ventricular mass index, and left ventricular end-diastolic volume index (correlation coefficient: 0.49; 95% confidence interval: 0.12–0.86, P <.01). Increased CMR ECV was more associated with EAT in those with advanced age, male sex, LGE on magnetic resonance imaging–LGE images, and less left ventricular end-diastolic volume index. Conclusions EAT volume is highly associated with CMR ECV independent of traditional risk factors and left ventricular mass or volume. Whether EAT plays a role in the long-term prognosis of HF requires future investigation.
原文英語
頁(從 - 到)1421-1431
頁數11
期刊Journal of Clinical Lipidology
11
發行號6
DOIs
出版狀態已發佈 - 十一月 1 2017
對外發佈Yes

指紋

Fibrosis
Heart Failure
Fats
Magnetic Resonance Imaging
Stroke Volume
Systolic Heart Failure
Intra-Abdominal Fat
Gadolinium
Magnetic Resonance Spectroscopy
Obesity
Confidence Intervals
Hypertension
Inflammation
Control Groups

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

引用此文

Evolutional change in epicardial fat and its correlation with myocardial diffuse fibrosis in heart failure patients. / Wu, Cho Kai; Tsai, Hao Yuan; Su, Mao Yuan M.; Wu, Yi Fan; Hwang, Juey Jen; Lin, Jiunn Lee; Lin, Lian Yu; Chen, Jien Jiun.

於: Journal of Clinical Lipidology, 卷 11, 編號 6, 01.11.2017, p. 1421-1431.

研究成果: 雜誌貢獻文章

Wu, Cho Kai ; Tsai, Hao Yuan ; Su, Mao Yuan M. ; Wu, Yi Fan ; Hwang, Juey Jen ; Lin, Jiunn Lee ; Lin, Lian Yu ; Chen, Jien Jiun. / Evolutional change in epicardial fat and its correlation with myocardial diffuse fibrosis in heart failure patients. 於: Journal of Clinical Lipidology. 2017 ; 卷 11, 編號 6. 頁 1421-1431.
@article{c2feb6b8e23743c7bbb9af55a4fac791,
title = "Evolutional change in epicardial fat and its correlation with myocardial diffuse fibrosis in heart failure patients",
abstract = "Objectives The aim of this study was to characterize the characteristics of epicardial fat (EAT) in different stage heart failure (HF) patients and its relationship between cardiac fibrosis. Background EAT is visceral adipose tissue that possesses inflammatory properties. Inflammation and obesity are associated with cardiac fibrosis, but the relationship between cardiac fibrosis and EAT is unknown. Methods EAT volume was measured using cardiac magnetic resonance imaging (CMR) in 180 subjects: 58 patients with systolic HF, 63 patients with HF and preserved ejection fraction, and 59 patients without HF. CMR derived myocardial extracellular volume (ECV) was used for fibrosis quantification. Results Patients with systolic HF had significantly more EAT compared with patients with HF and preserved ejection fraction or the control group (patients without HF) (indexed EAT volume [mL/m2], 27.0 [22.7–31.6] vs 25.6 [21.4–31.2] and 24.2 [21.0–27.6], P <.05). The adjusted EAT amount was associated with ECV completely independent of age, hypertension, diabetes, etiology of HF, left ventricular ejection fraction, CMR–late gadolinium enhancement (LGE), left ventricular mass index, and left ventricular end-diastolic volume index (correlation coefficient: 0.49; 95{\%} confidence interval: 0.12–0.86, P <.01). Increased CMR ECV was more associated with EAT in those with advanced age, male sex, LGE on magnetic resonance imaging–LGE images, and less left ventricular end-diastolic volume index. Conclusions EAT volume is highly associated with CMR ECV independent of traditional risk factors and left ventricular mass or volume. Whether EAT plays a role in the long-term prognosis of HF requires future investigation.",
keywords = "Cardiac magnetic resonance imaging, Epicardial fat, Heart failure, Myocardial fibrosis",
author = "Wu, {Cho Kai} and Tsai, {Hao Yuan} and Su, {Mao Yuan M.} and Wu, {Yi Fan} and Hwang, {Juey Jen} and Lin, {Jiunn Lee} and Lin, {Lian Yu} and Chen, {Jien Jiun}",
year = "2017",
month = "11",
day = "1",
doi = "10.1016/j.jacl.2017.08.018",
language = "English",
volume = "11",
pages = "1421--1431",
journal = "Journal of Clinical Lipidology",
issn = "1933-2874",
publisher = "Elsevier BV",
number = "6",

}

TY - JOUR

T1 - Evolutional change in epicardial fat and its correlation with myocardial diffuse fibrosis in heart failure patients

AU - Wu, Cho Kai

AU - Tsai, Hao Yuan

AU - Su, Mao Yuan M.

AU - Wu, Yi Fan

AU - Hwang, Juey Jen

AU - Lin, Jiunn Lee

AU - Lin, Lian Yu

AU - Chen, Jien Jiun

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Objectives The aim of this study was to characterize the characteristics of epicardial fat (EAT) in different stage heart failure (HF) patients and its relationship between cardiac fibrosis. Background EAT is visceral adipose tissue that possesses inflammatory properties. Inflammation and obesity are associated with cardiac fibrosis, but the relationship between cardiac fibrosis and EAT is unknown. Methods EAT volume was measured using cardiac magnetic resonance imaging (CMR) in 180 subjects: 58 patients with systolic HF, 63 patients with HF and preserved ejection fraction, and 59 patients without HF. CMR derived myocardial extracellular volume (ECV) was used for fibrosis quantification. Results Patients with systolic HF had significantly more EAT compared with patients with HF and preserved ejection fraction or the control group (patients without HF) (indexed EAT volume [mL/m2], 27.0 [22.7–31.6] vs 25.6 [21.4–31.2] and 24.2 [21.0–27.6], P <.05). The adjusted EAT amount was associated with ECV completely independent of age, hypertension, diabetes, etiology of HF, left ventricular ejection fraction, CMR–late gadolinium enhancement (LGE), left ventricular mass index, and left ventricular end-diastolic volume index (correlation coefficient: 0.49; 95% confidence interval: 0.12–0.86, P <.01). Increased CMR ECV was more associated with EAT in those with advanced age, male sex, LGE on magnetic resonance imaging–LGE images, and less left ventricular end-diastolic volume index. Conclusions EAT volume is highly associated with CMR ECV independent of traditional risk factors and left ventricular mass or volume. Whether EAT plays a role in the long-term prognosis of HF requires future investigation.

AB - Objectives The aim of this study was to characterize the characteristics of epicardial fat (EAT) in different stage heart failure (HF) patients and its relationship between cardiac fibrosis. Background EAT is visceral adipose tissue that possesses inflammatory properties. Inflammation and obesity are associated with cardiac fibrosis, but the relationship between cardiac fibrosis and EAT is unknown. Methods EAT volume was measured using cardiac magnetic resonance imaging (CMR) in 180 subjects: 58 patients with systolic HF, 63 patients with HF and preserved ejection fraction, and 59 patients without HF. CMR derived myocardial extracellular volume (ECV) was used for fibrosis quantification. Results Patients with systolic HF had significantly more EAT compared with patients with HF and preserved ejection fraction or the control group (patients without HF) (indexed EAT volume [mL/m2], 27.0 [22.7–31.6] vs 25.6 [21.4–31.2] and 24.2 [21.0–27.6], P <.05). The adjusted EAT amount was associated with ECV completely independent of age, hypertension, diabetes, etiology of HF, left ventricular ejection fraction, CMR–late gadolinium enhancement (LGE), left ventricular mass index, and left ventricular end-diastolic volume index (correlation coefficient: 0.49; 95% confidence interval: 0.12–0.86, P <.01). Increased CMR ECV was more associated with EAT in those with advanced age, male sex, LGE on magnetic resonance imaging–LGE images, and less left ventricular end-diastolic volume index. Conclusions EAT volume is highly associated with CMR ECV independent of traditional risk factors and left ventricular mass or volume. Whether EAT plays a role in the long-term prognosis of HF requires future investigation.

KW - Cardiac magnetic resonance imaging

KW - Epicardial fat

KW - Heart failure

KW - Myocardial fibrosis

UR - http://www.scopus.com/inward/record.url?scp=85031406636&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85031406636&partnerID=8YFLogxK

U2 - 10.1016/j.jacl.2017.08.018

DO - 10.1016/j.jacl.2017.08.018

M3 - Article

C2 - 29050981

AN - SCOPUS:85031406636

VL - 11

SP - 1421

EP - 1431

JO - Journal of Clinical Lipidology

JF - Journal of Clinical Lipidology

SN - 1933-2874

IS - 6

ER -