Evidence to support testing of resveratrol for efficacy in rheumatoid arthritis

Paul J. Davis, Ole Vang, Ran Meng, Dana Crawford, Jenn Haung Lai, Feng Cheng Liu, Heng Yuan Tang, Hung Yun Lin

研究成果: 書貢獻/報告類型章節

摘要

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of multiple joints with the potential to cause joint destruction and functional disability. While the effects can be seen in many tissues and organs, attacks are primarily against the synovial joints. Resveratrol, a phytoalexin found in grape skins and other plants, has been shown to exhibit anti-proliferative, anti-inflammatory, and anti-catabolic properties. Studies have suggested that these properties can be harnessed to reduce the effects associated with rheumatoid arthritis. This review will focus on the mechanisms involved in the development of rheumatoid arthritis, and the inhibitory effects of resveratrol. The risk factors involved in rheumatoid arthritis such as elevated cytokines: tumor necrosis factor-α (TNF-α), and Interleukin 1β (IL-1β); activation of the NF-κB signaling cascade; and enhanced cyclooxygenase-2 (COX-2) activity will be addressed. Mechanisms of resveratrol-induced inhibition of nuclear factor-κB (NF-κB) activation and IL-1β production will be discussed, as well as resveratrol's induction of COX-2 nuclear accumulation and subsequent apoptosis. Resveratrol induces nuclear accumulation of COX-2 facilitating apoptosis. Finally, the potential role of inducible COX-2-dependent apoptosis in arthritis relief will be investigated.
原文英語
主出版物標題Resveratrol: Sources, Production and Health Benefits
發行者Nova Science Publishers, Inc.
頁面275-296
頁數22
ISBN(列印)9781620819975
出版狀態已發佈 - 二月 2013
對外發佈

ASJC Scopus subject areas

  • 生物化學、遺傳與分子生物學 (全部)

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