Evidence of alterations of Beta-endorphin levels and Mu-opioid receptor gene expression in bipolar disorder

Andrea Escelsior, Bruno Sterlini, Samuele Tardito, Tiziana Altosole, Paola Magioncalda, Matteo Martino, Gianluca Serafini, Martino Belveri Murri, Andrea Aguglia, Andrea Amerio, Beatriz Pereira da Silva, Alice Trabucco, Daniela Fenoglio, Gilberto Filaci, Mario Amore

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1 引文 斯高帕斯(Scopus)

摘要

Despite the well-recognized effects of endogenous opioids on mood and behavior, research on its role in bipolar disorder (BD) is still limited to small or anecdotal reports. Considering that Beta-endorphins (β-END) and Mu-opioid receptors (MOR), in particular, have a crucial activity in affective modulation, we hypothesized their alteration in BD. A cross-sectional study was conducted. We compared: (1) BD type I (BD-I) patients (n = 50) vs healthy controls (n = 27), (2) two BD-I subject subgroups: manic (MAN; n = 25) vs depressed (DEP; n = 25) subjects. Plasma levels of β-END and MOR gene expression in peripheral blood mononuclear cells were analyzed using ELISA Immunoassay qRT-PCR. We found that subjects with BD exhibited a significant upregulation of MOR gene expression and a decrease of β-END (p
原文英語
文章編號114787
期刊Psychiatry Research
316
DOIs
出版狀態已發佈 - 10月 2022

ASJC Scopus subject areas

  • 精神病學和心理健康
  • 生物精神病學

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