Evidence for the reversibility of cellular DNA lesion induced by mammalian topoisomerase II poisons

Y. H. Hsiang, Leroy-Fong Liu

研究成果: 雜誌貢獻文章同行評審

82 引文 斯高帕斯(Scopus)

摘要

Like many intercalative antitumor drugs, the nonintercalative antitumor drug epipodophyllotoxin VM-26 (teniposide) induces topoisomerase II-linked DNA breaks as revealed by cell lysis with a strong protein denaturant such as sodium dodecyl sulfate or alkali. We show that the majority of topoisomerase II-linked DNA breaks reflect the formation of reversible topoisomerase II-DNA cleavable complexes in drug-treated cells by demonstrating the reversibility of this unusual type of DNA damage at elevated temperatures (e.g. 65°C).

原文英語
頁(從 - 到)9713-9715
頁數3
期刊Journal of Biological Chemistry
264
發行號17
出版狀態已發佈 - 1989
對外發佈Yes

ASJC Scopus subject areas

  • Biochemistry

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