Evidence for the involvement of dopamine D1 and D2 receptors in mediating the decrease of food intake during repeated treatment with amphetamine

T. Y. Chen, S. L. Duh, C. C. Huang, T. B. Lin, D. Y. Kuo

研究成果: 雜誌貢獻文章

39 引文 (Scopus)

摘要

Repeated treatment with amphetamine (AMPH), a well-known anorectic agent, into animals could induce anorexia on day 1 and produce a gradual reversion of food intake (tolerant anorexia) on the following days. It is unknown whether these feeding changes are related to dopamine (DA) and/or noradrenergic neurotransmission. Thus, the present study investigated the subtype of receptor mediating AMPH-induced anorexia. Daily food intake was measured after various drugs were given. Pretreatment with haloperidol, an antagonist of DA receptors, may lead to inhibition of AMPH-induced anorexia. However, pretreatment with the α-adrenoceptor antagonist phentolamine, and the β-adrenoceptor antagonist propranolol, failed to modify the action of AMPH, suggesting the involvement of DA receptors but not adrenoceptors in the action of AMPH-induced anorexia. Furthermore, pretreatment with SCH 23390 at a dose sufficient to block D1 receptors or pimozide at a dose sufficient to inhibit D2 receptors blocked AMPH-induced anorexia, indicating the involvement of D1 and D2 receptors. In a study of tolerant anorexia, repeated treatment with the D1/D2 agonist apomorphine, but not the D1 agonist SKF 38393 or D2 agonist quinpirole, induced an AMPH-like tolerant feeding response, providing evidence for conjoint action of D1 and D2 receptors in the effect. The present results suggest that both D1 and D2 receptors are involved in anorexia and tolerant anorexia induced by chronic intermittent administration of AMPH.

原文英語
頁(從 - 到)462-466
頁數5
期刊Journal of Biomedical Science
8
發行號6
DOIs
出版狀態已發佈 - 2001
對外發佈Yes

指紋

Dopamine D1 Receptors
Dopamine D2 Receptors
Anorexia
Amphetamine
Eating
Adrenergic Receptors
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Pimozide
Quinpirole
Appetite Depressants
Dopamine Antagonists
Apomorphine
Phentolamine
Dopamine Receptors
Haloperidol
Propranolol
Synaptic Transmission
Dopamine
Animals

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

引用此文

Evidence for the involvement of dopamine D1 and D2 receptors in mediating the decrease of food intake during repeated treatment with amphetamine. / Chen, T. Y.; Duh, S. L.; Huang, C. C.; Lin, T. B.; Kuo, D. Y.

於: Journal of Biomedical Science, 卷 8, 編號 6, 2001, p. 462-466.

研究成果: 雜誌貢獻文章

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abstract = "Repeated treatment with amphetamine (AMPH), a well-known anorectic agent, into animals could induce anorexia on day 1 and produce a gradual reversion of food intake (tolerant anorexia) on the following days. It is unknown whether these feeding changes are related to dopamine (DA) and/or noradrenergic neurotransmission. Thus, the present study investigated the subtype of receptor mediating AMPH-induced anorexia. Daily food intake was measured after various drugs were given. Pretreatment with haloperidol, an antagonist of DA receptors, may lead to inhibition of AMPH-induced anorexia. However, pretreatment with the α-adrenoceptor antagonist phentolamine, and the β-adrenoceptor antagonist propranolol, failed to modify the action of AMPH, suggesting the involvement of DA receptors but not adrenoceptors in the action of AMPH-induced anorexia. Furthermore, pretreatment with SCH 23390 at a dose sufficient to block D1 receptors or pimozide at a dose sufficient to inhibit D2 receptors blocked AMPH-induced anorexia, indicating the involvement of D1 and D2 receptors. In a study of tolerant anorexia, repeated treatment with the D1/D2 agonist apomorphine, but not the D1 agonist SKF 38393 or D2 agonist quinpirole, induced an AMPH-like tolerant feeding response, providing evidence for conjoint action of D1 and D2 receptors in the effect. The present results suggest that both D1 and D2 receptors are involved in anorexia and tolerant anorexia induced by chronic intermittent administration of AMPH.",
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