Evaluation of white sweet potato tube-feeding formula in elderly diabetic patients: A randomized controlled trial

Chiao Ming Chen, Chun Kuang Shih, Yi Jing Su, Kuan Un Cheang, Shu Fang Lo, Sing Chung Li

研究成果: 雜誌貢獻文章

摘要

Background: Elderly people with type 2 diabetes mellitus (T2DM) have an increased risk of diabetes-related microvascular and macrovascular complications, thus diabetic patients with a functioning gastrointestinal tract but without sufficient oral intake require enteral nutrition (EN) formulas to control blood glucose. White sweet potato (WSP) was a kind of sweet potato could provide a healthy carbohydrate source to EN formula. The aim of this study was to examine at risk of malnutrition T2DM patients whether a WSP-EN would attenuate glucose response and elevate nutritional index compared to a standard polymeric formulas. Methods: In this randomized, parallel, placebo-controlled, pilot clinical trial to investigate the effects of EN with WSP on aged residents with T2DM in long-term care institutions. In total, 54 eligible participants were randomly assigned to either the non-WSP-EN or WSP-EN group. For 60 days, the WSP-EN group received a WSP formula through nasogastric tube via a stoma with a large-bore syringe. The participants received EN of standard polymeric formulas without WSP in the non-WSP-EN group. Results: The body weight, body mass index, Mini Nutritional Assessment score, and Geriatric Nutritional Risk Index were significantly higher in the WSP-EN group (p < 0.05). Moreover, the WSP-EN intervention reduced glycated hemoglobin levels (6.73% ± 1.47% vs. 6.40% ± 1.16%), but increased transferrin (223.06 ± 38.85 vs. 245.85 ± 46.08 mg/dL), high-density lipoprotein cholesterol (42.13 ± 10.56 vs. 44.25 ± 8.43 mg/dL), and vitamin A (2.45 ± 0.77 vs 2.74 ± 0.93 μM) levels (p < 0.05). In addition, there was no important side effects including gastrointestinal intolerance with prescribed doses in our WSP-EN treated patients when compared with control ones. Conclusions: The results suggest WSP incorporated into enteral formulas can improve nutrition status and glycemic control in elderly diabetic patients. Trial registration: NCT02711839, registered 27 May 2015.
原文英語
文章編號70
期刊Nutrition and Metabolism
16
發行號1
DOIs
出版狀態已發佈 - 十月 16 2019

指紋

Ipomoea batatas
Enteral Nutrition
Randomized Controlled Trials
Nutrition Assessment
Type 2 Diabetes Mellitus
Controlled Clinical Trials
Syringes
Glycosylated Hemoglobin A
Long-Term Care
Diabetes Complications
Transferrin
Nutritional Status
Vitamin A
Malnutrition
Geriatrics

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

引用此文

Evaluation of white sweet potato tube-feeding formula in elderly diabetic patients : A randomized controlled trial. / Chen, Chiao Ming; Shih, Chun Kuang; Su, Yi Jing; Cheang, Kuan Un; Lo, Shu Fang; Li, Sing Chung.

於: Nutrition and Metabolism, 卷 16, 編號 1, 70, 16.10.2019.

研究成果: 雜誌貢獻文章

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title = "Evaluation of white sweet potato tube-feeding formula in elderly diabetic patients: A randomized controlled trial",
abstract = "Background: Elderly people with type 2 diabetes mellitus (T2DM) have an increased risk of diabetes-related microvascular and macrovascular complications, thus diabetic patients with a functioning gastrointestinal tract but without sufficient oral intake require enteral nutrition (EN) formulas to control blood glucose. White sweet potato (WSP) was a kind of sweet potato could provide a healthy carbohydrate source to EN formula. The aim of this study was to examine at risk of malnutrition T2DM patients whether a WSP-EN would attenuate glucose response and elevate nutritional index compared to a standard polymeric formulas. Methods: In this randomized, parallel, placebo-controlled, pilot clinical trial to investigate the effects of EN with WSP on aged residents with T2DM in long-term care institutions. In total, 54 eligible participants were randomly assigned to either the non-WSP-EN or WSP-EN group. For 60 days, the WSP-EN group received a WSP formula through nasogastric tube via a stoma with a large-bore syringe. The participants received EN of standard polymeric formulas without WSP in the non-WSP-EN group. Results: The body weight, body mass index, Mini Nutritional Assessment score, and Geriatric Nutritional Risk Index were significantly higher in the WSP-EN group (p < 0.05). Moreover, the WSP-EN intervention reduced glycated hemoglobin levels (6.73{\%} ± 1.47{\%} vs. 6.40{\%} ± 1.16{\%}), but increased transferrin (223.06 ± 38.85 vs. 245.85 ± 46.08 mg/dL), high-density lipoprotein cholesterol (42.13 ± 10.56 vs. 44.25 ± 8.43 mg/dL), and vitamin A (2.45 ± 0.77 vs 2.74 ± 0.93 μM) levels (p < 0.05). In addition, there was no important side effects including gastrointestinal intolerance with prescribed doses in our WSP-EN treated patients when compared with control ones. Conclusions: The results suggest WSP incorporated into enteral formulas can improve nutrition status and glycemic control in elderly diabetic patients. Trial registration: NCT02711839, registered 27 May 2015.",
keywords = "Enteral nutrition, Tube feeding, Type 2 diabetes mellitus, White sweet potato",
author = "Chen, {Chiao Ming} and Shih, {Chun Kuang} and Su, {Yi Jing} and Cheang, {Kuan Un} and Lo, {Shu Fang} and Li, {Sing Chung}",
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TY - JOUR

T1 - Evaluation of white sweet potato tube-feeding formula in elderly diabetic patients

T2 - A randomized controlled trial

AU - Chen, Chiao Ming

AU - Shih, Chun Kuang

AU - Su, Yi Jing

AU - Cheang, Kuan Un

AU - Lo, Shu Fang

AU - Li, Sing Chung

PY - 2019/10/16

Y1 - 2019/10/16

N2 - Background: Elderly people with type 2 diabetes mellitus (T2DM) have an increased risk of diabetes-related microvascular and macrovascular complications, thus diabetic patients with a functioning gastrointestinal tract but without sufficient oral intake require enteral nutrition (EN) formulas to control blood glucose. White sweet potato (WSP) was a kind of sweet potato could provide a healthy carbohydrate source to EN formula. The aim of this study was to examine at risk of malnutrition T2DM patients whether a WSP-EN would attenuate glucose response and elevate nutritional index compared to a standard polymeric formulas. Methods: In this randomized, parallel, placebo-controlled, pilot clinical trial to investigate the effects of EN with WSP on aged residents with T2DM in long-term care institutions. In total, 54 eligible participants were randomly assigned to either the non-WSP-EN or WSP-EN group. For 60 days, the WSP-EN group received a WSP formula through nasogastric tube via a stoma with a large-bore syringe. The participants received EN of standard polymeric formulas without WSP in the non-WSP-EN group. Results: The body weight, body mass index, Mini Nutritional Assessment score, and Geriatric Nutritional Risk Index were significantly higher in the WSP-EN group (p < 0.05). Moreover, the WSP-EN intervention reduced glycated hemoglobin levels (6.73% ± 1.47% vs. 6.40% ± 1.16%), but increased transferrin (223.06 ± 38.85 vs. 245.85 ± 46.08 mg/dL), high-density lipoprotein cholesterol (42.13 ± 10.56 vs. 44.25 ± 8.43 mg/dL), and vitamin A (2.45 ± 0.77 vs 2.74 ± 0.93 μM) levels (p < 0.05). In addition, there was no important side effects including gastrointestinal intolerance with prescribed doses in our WSP-EN treated patients when compared with control ones. Conclusions: The results suggest WSP incorporated into enteral formulas can improve nutrition status and glycemic control in elderly diabetic patients. Trial registration: NCT02711839, registered 27 May 2015.

AB - Background: Elderly people with type 2 diabetes mellitus (T2DM) have an increased risk of diabetes-related microvascular and macrovascular complications, thus diabetic patients with a functioning gastrointestinal tract but without sufficient oral intake require enteral nutrition (EN) formulas to control blood glucose. White sweet potato (WSP) was a kind of sweet potato could provide a healthy carbohydrate source to EN formula. The aim of this study was to examine at risk of malnutrition T2DM patients whether a WSP-EN would attenuate glucose response and elevate nutritional index compared to a standard polymeric formulas. Methods: In this randomized, parallel, placebo-controlled, pilot clinical trial to investigate the effects of EN with WSP on aged residents with T2DM in long-term care institutions. In total, 54 eligible participants were randomly assigned to either the non-WSP-EN or WSP-EN group. For 60 days, the WSP-EN group received a WSP formula through nasogastric tube via a stoma with a large-bore syringe. The participants received EN of standard polymeric formulas without WSP in the non-WSP-EN group. Results: The body weight, body mass index, Mini Nutritional Assessment score, and Geriatric Nutritional Risk Index were significantly higher in the WSP-EN group (p < 0.05). Moreover, the WSP-EN intervention reduced glycated hemoglobin levels (6.73% ± 1.47% vs. 6.40% ± 1.16%), but increased transferrin (223.06 ± 38.85 vs. 245.85 ± 46.08 mg/dL), high-density lipoprotein cholesterol (42.13 ± 10.56 vs. 44.25 ± 8.43 mg/dL), and vitamin A (2.45 ± 0.77 vs 2.74 ± 0.93 μM) levels (p < 0.05). In addition, there was no important side effects including gastrointestinal intolerance with prescribed doses in our WSP-EN treated patients when compared with control ones. Conclusions: The results suggest WSP incorporated into enteral formulas can improve nutrition status and glycemic control in elderly diabetic patients. Trial registration: NCT02711839, registered 27 May 2015.

KW - Enteral nutrition

KW - Tube feeding

KW - Type 2 diabetes mellitus

KW - White sweet potato

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