Evaluation of the grafting efficacy of active biomolecules of phosphatidylcholine and type i collagen on polyether ether ketone: In vitro and in vivo

Jian Chih Chen, Chih Hua Chen, Kai Chi Chang, Shih Ming Liu, Chia Ling Ko, Chi Jen Shih, Ying Sui Sun, Wen Cheng Chen

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

Biomolecule grafting on polyether ether ketone (PEEK) was used to improve cell affinity caused by surface inertness. This study demonstrated the sequence-polished (P) and sulfonated (SA) PEEK modification to make a 3D structure, active biomolecule graftings through PEEK silylation (SA/SI) and then processed with phosphatidylcholine (with silylation of SA/SI/PC; without SA/PC) and type I collagen (COL I, with silylation of SA/SI/C; without SA/C). Different modified PEEKs were implanted for 4, 8, and 12 weeks for histology. Sulfonated PEEK of SA showed the surface roughness was significantly increased; after the silylation of SA/SI, the hydrophilic nature was remarkably improved. The biomolecules were effectively grafted through silylation, and the cells showed improved attachment after 1 h. Furthermore, the SA/SI/PC group showed good in vitro mineralization. The new bone tissues were integrated into the 3D porous structures of SA/SI/PC and SA/SI/C in vivo making PEEK a potential alternative to metals in orthopedic implants.
原文英語
文章編號2081
期刊Polymers
13
發行號13
DOIs
出版狀態已發佈 - 七月 2021

ASJC Scopus subject areas

  • 化學 (全部)
  • 聚合物和塑料

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