Evaluation of the antioxidant and melanogenesis inhibitory properties of Pracparatum Mungo (Lu-Do Huang)

Yu Yu Kao, Tien Fu Chuang, Shiou Huei Chao, Jo Hsuan Yang, Yu Chuan Lin, Hui Yu Huang

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)

摘要

Pracparatum mungo (Lu-Do Huang) is a traditional Chinese functional medicine made from the natural fermentation of mung bean (L Dòu) mixed with other Chinese medicines. It has been recognized as having liver protecting and detoxifying effects. As mung beans have been verified to possess anti-inflammatory, antioxidant, antipyretic, and whitening actions, the present research utilized thein vitro , ex vivo , and in vivo experimental models to investigate the antioxidant and melanin inhibiting effects of P. mungo on the skin. The in vitro experiment revealed that P. mungo methanol extract (PMME) and P. mungo ethanol extract (PMEE) possess the capacity to clear α,α-diphenyl-2-picrylhydrazyl (DPPH) radicals and inhibit tyrosinase activity. The ex vivo experiment indicated that PMEE can promote the growth of MDCK cells and increase the enzymatic activities of superoxide dismutase (SOD) and catalase in MDCK cells. On the other hand, PMME and PMEE can suppress the proliferation of A375 cells, and PMEE can reduce the enzymatic activities of SOD and catalase in A375 cells. The in vivo results showed that P. mungo can enhance the enzymatic performance of SOD, Catalase, and glutathione peroxidase (GPx) in the liver. The results also showed that P. mungo has antioxidant characteristics and can inhibit tyrosinase activity, thereby promoting the growth of skin tissues and suppressing the proliferation of A375 cells, and thus enhancing the effects that the antioxidant enzymatic performance has on the liver. These results can be applied in the development of tyrosinase inhibitors or antioxidants used for the inhibition of melanin biosynthesis or for auto-oxidation in further industrial applications, particularly those relating to functional food or cosmetic compositions.

原文英語
頁(從 - 到)163-170
頁數8
期刊Journal of Traditional and Complementary Medicine
3
發行號3
DOIs
出版狀態已發佈 - 一月 1 2013
對外發佈Yes

ASJC Scopus subject areas

  • Complementary and alternative medicine

指紋 深入研究「Evaluation of the antioxidant and melanogenesis inhibitory properties of Pracparatum Mungo (Lu-Do Huang)」主題。共同形成了獨特的指紋。

  • 引用此