@article{5d84b6c9560b405abea6c5ee6eb6648a,
title = "Evaluation of serum amyloid a as a biomarker for gastric cancer",
abstract = "Background: Serum amyloid A (SAA) is a useful biomarker for gastric cancer in an animal model. We investigated the potential of SAA as a biomarker for gastric cancer in humans. Methods: Serum levels of SAA from 96 gastric cancer patients were measured before and after curative gastrectomy; 32 patients with gastric ulcers and 52 healthy subjects were the control groups. The immunohistochemical study was performed to evaluate the protein expression over gastric cancer tissue slides. Results: The mean SAA concentration was higher in gastric cancer patients (88.54 ± 50.44 mg/l) than in healthy subjects (3.36 ± 2.29 mg/l) and gastric ulcer patients (10.48 ± 8.97 mg/l) (P <.05). The SAA concentration was associated with tumor stage (P = .0244) and location (P = .0016) but not with Lauren's histological type (P = .839). In the multivariate analysis, SAA level was correlated with tumor location (P <.0001) and lymph node status (P <.05). During follow-up, the mean SAA concentration increased significantly in 24 patients with tumor recurrence (P <.05) but did not change in 77 patients without recurrence. In the survival analysis, patients with SAA levels > 97 mg/l had a nearly fourfold increase in risk of death. Immunoreactivity was most prominent in blood vessel regions but not within cancer cells. Conclusions: These data not only demonstrated SAA was useful in predicting survival of patients with gastric cancer, but they also showed that SAA was a valuable tool for postoperative follow-up. {\textcopyright} 2006 Society of Surgical Oncology.",
keywords = "Mass spectrometry (MS), Serum amyloid A (SAA) protein, Serum marker, Stomach neoplasm, biological marker, serum amyloid A, article, blood vessel, cancer cell, cancer patient, cancer survival, concentration response, controlled study, correlation analysis, disease marker, evaluation, follow up, gastrectomy, human, human tissue, immunohistochemistry, immunoreactivity, lymph node, major clinical study, measurement, mortality, multivariate analysis, protein expression, stomach cancer, stomach ulcer, tissue section, tumor recurrence, Adenocarcinoma, Aged, Female, Gastrectomy, Humans, Immunohistochemistry, Male, Middle Aged, Serum Amyloid A Protein, Stomach Neoplasms, Stomach Ulcer, Survival Analysis, Tumor Markers, Biological",
author = "De-Chuan Chan and Cheng-Jueng Chen and Heng-Cheng Chu and Wei-Kuo Chang and Jyh-Cherng Yu and Yu-Ju Chen and Li-Li Wen and Su-Ching Huang and Chih-Hung Ku and Yao-Chi Liu and Jenn-Han Chen",
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year = "2007",
doi = "10.1245/s10434-006-9091-z",
language = "English",
volume = "14",
pages = "84--93",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer New York",
number = "1",
}
