Evaluation of PVA/dextran/chitosan hydrogel for wound dressing

Shin Ping Lin, Kai Yin Lo, Tien Ni Tseng, Jui Ming Liu, Ting Yu Shih, Kuan Chen Cheng

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

Developing a multiple functional wound dressing suitable for different stages of wound healing is important for patients with special wound such as burn or decubital ulcers. In this study, poly (vinyl alcohol) (PVA), dextran, and chitosan are integrated to produce ideal wound dressing where glutaraldehyde (GA) is used as the cross-linker. The result demonstrated that 6% PVA hydrogel with 0.25% chitosan was found to provide antimicrobial ability. The PVA/chitosan hydrogel combined with 4% dextran utilizing GA cross-linking also presents the high cell proliferation ability, which suggests that the hydrogel is potential as a wound dressing. In the following physical analyses, the addition of chitosan and dextran appeared to promote the thermostability, mechanical properties, water retention, and moisturizing ability in the PVA hydrogel. In conclusion, the PVA/chitosan/dextran hydrogel has promising potential such as high water content, antimicrobial property, and well cell proliferation, which can be applied to wound healing application.

原文英語
頁(從 - 到)15-30
頁數16
期刊Cellular Polymers
38
發行號1-2
DOIs
出版狀態已發佈 - 一月 1 2019
對外發佈Yes

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry

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