Evaluation of optimal cerebral perfusion pressure in severe traumatic brain injury

Jia-Wei Lin, Jo-Ting Tsai, Chien-Min Lin, Liang-Ming Lee, Kuo-Sheng Hung, Sheng Jean Huang, Sheng Huang Hsiao, Wen Yu Chung, Ming Dar Tsai, Chung Ching Hsia, Ching Chang Hung, Wen-Ta Chiu

研究成果: 書貢獻/報告類型章節

5 引文 斯高帕斯(Scopus)


Traumatic brain injury (TBI) is a major cause of death and disability. In the 2000 guidelines, one of the suggestions for TBI treatment was to maintain cerebral perfusion pressure (CPP) < 70 mmHg. But in the 2003 guidelines, the suggestion was changed to < 60 mrnHg. There have been some discrepancies of opinions about this recommendation in recent publications. In this study, we retrospectively reviewed 305 severe TBI (STBI) patients with Glasgow Coma Scales (GCS) <8 between January 1, 2002 and March 31, 2003. The study group was stratified according to use or nonuse of intracranial pressure (ICP) monitoring, ICP levels, ages, and GCS levels in order to test the correlation between CCP and the prognosis. The patients <50-year-old, with higher GCS level, with ICP monitoring, and with ICP levels <20 mrnHg had lower mortality rates and better prognosis (GOS) (p<0.05 or 0.001). The patients in the GCS 3-5 subgroup had a significantly lower mortality and better prognosis if the CPP value was maintained higher than 70 mmHg (p < 0.05) The optimal CPP maintained ≤ 60 mmHg did not fit in all STBI patients. Our study concludes that it is critical to maintain CPP substantially higher in lower GCS level patients.
主出版物標題Acta Neurochirurgica, Supplementum
出版狀態已發佈 - 2008


名字Acta Neurochirurgica, Supplementum

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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