Evaluation of Cyberknife Treatment Planning for Prostate Cancer using the Conformal Index and the Tumor Control Probability

貢獻的翻譯標題: 以劑量包覆順型度數學模型和腫瘤控制機率模式評估攝護腺癌在放射手術電腦刀治療計畫系統

Chia Chun Kuo, Hsiao-Wei Yu, Kuang Wei Huang, Chiu-Ping Chen, Tao Sang Chung, Jeng-Fong Chiou, Jo-Ting Tsai

研究成果: 雜誌貢獻文章

摘要

目的:本研究在於利用劑量包覆順型度數學模型,分析電腦刀放射治療技術輻照區域劑量與周圍器官體積彼此間順型度之關係。配合腫瘤控制機率公式運算分析攝護腺癌經放射治療後腫瘤控制機率,以期更能適用於電腦刀治療計畫的分析。
材料與方法:本研究回溯性收集六名攝護腺腫瘤患者接受低分次電腦刀立體定位放射治療計畫。給予劑量分別為37.5Gy分五次治療,42Gy分五次治療,和32Gy分四次治療。計算劑量包覆順型度及腫瘤控制機率,並分析計算結果以作為評估電腦刀計畫系統的參考。
結果:電腦刀治療計畫系統本身所提供的劑量包覆順型度計算值在腫瘤控制機率達98.3%以上時均在1.483以下。而經過以週遭重要器官加入考量的模式計算後,增加劑量包覆順型度的差異性提供作為治療計畫的評估。
結論:放射線手術治療計畫給予較高的生物等效劑量,故適用於電腦刀劑量包覆順型度模式,必須能兼顧分析放射治療劑量區最佳的腫瘤體積包覆特性,和擴散到周圍的正常組織高劑量分佈。本文中所運算的模式可以用來評估及比較放射治療計畫。
原文英語
頁(從 - 到)301-310
頁數10
期刊放射治療與腫瘤學
15
發行號4
DOIs
出版狀態已發佈 - 2008

指紋

Prostatic Neoplasms
Neoplasms
Radiosurgery
Prescriptions
Radiotherapy
Therapeutics
Retrospective Studies

Keywords

  • 腫瘤包覆順型度
  • 腫瘤控制機率模式
  • 立體定位放射線手術
  • 電腦刀

引用此文

Evaluation of Cyberknife Treatment Planning for Prostate Cancer using the Conformal Index and the Tumor Control Probability. / Kuo, Chia Chun; Yu, Hsiao-Wei ; Huang, Kuang Wei; Chen, Chiu-Ping; Chung, Tao Sang; Chiou, Jeng-Fong; Tsai, Jo-Ting.

於: 放射治療與腫瘤學, 卷 15, 編號 4, 2008, p. 301-310.

研究成果: 雜誌貢獻文章

Kuo, Chia Chun ; Yu, Hsiao-Wei ; Huang, Kuang Wei ; Chen, Chiu-Ping ; Chung, Tao Sang ; Chiou, Jeng-Fong ; Tsai, Jo-Ting. / Evaluation of Cyberknife Treatment Planning for Prostate Cancer using the Conformal Index and the Tumor Control Probability. 於: 放射治療與腫瘤學. 2008 ; 卷 15, 編號 4. 頁 301-310.
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title = "Evaluation of Cyberknife Treatment Planning for Prostate Cancer using the Conformal Index and the Tumor Control Probability",
abstract = "Purpose: This study was to evaluate the feasibility of dose conformity and tumor control probability calculated for CyberKnife(superscript {\circledR}) hypofractionated planning for prostate cancer.Materials and Methods: Six patients with early prostate cancer were included in this retrospective study. They received stereotactic hypofractionation radiotherapy by CyberKnife(superscript {\circledR}). The dose prescriptions were 37.5 Gy in 5 fractions, 42 Gy in 5 fractions, or 32 Gy in 4 fractions. Dose conformity was calculated with three parameters: the conformity index (CI), the new conformity index (nCI) and the modified conformal index (mCOIN). A statistical analysis of the tumor control probability (TCP) was also calculated.Results: The CI and nCI of the CyberKnife(superscript {\circledR}) treatment planning system are all under 1.483. All the calculated TCP values were greater than 98.3{\%}. We added the factors pertaining to the critical organ and obtained the mCOINs. The mCOIN values were listed to compare the quality of treatment plans.Conclusion: The conformity index value can be used to evaluate the quality of radiosurgery planning. The mCOIN values are also feasible to compare the plans.",
keywords = "Conformity index, Tumor control probability, Stereotactic radiosurgery, CyberKnife, 腫瘤包覆順型度, 腫瘤控制機率模式, 立體定位放射線手術, 電腦刀",
author = "Kuo, {Chia Chun} and Hsiao-Wei Yu and Huang, {Kuang Wei} and Chiu-Ping Chen and Chung, {Tao Sang} and Jeng-Fong Chiou and Jo-Ting Tsai",
year = "2008",
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journal = "放射治療與腫瘤學",
issn = "1023-988x",
publisher = "台灣放射腫瘤學會",
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T1 - Evaluation of Cyberknife Treatment Planning for Prostate Cancer using the Conformal Index and the Tumor Control Probability

AU - Kuo, Chia Chun

AU - Yu, Hsiao-Wei

AU - Huang, Kuang Wei

AU - Chen, Chiu-Ping

AU - Chung, Tao Sang

AU - Chiou, Jeng-Fong

AU - Tsai, Jo-Ting

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N2 - Purpose: This study was to evaluate the feasibility of dose conformity and tumor control probability calculated for CyberKnife(superscript ®) hypofractionated planning for prostate cancer.Materials and Methods: Six patients with early prostate cancer were included in this retrospective study. They received stereotactic hypofractionation radiotherapy by CyberKnife(superscript ®). The dose prescriptions were 37.5 Gy in 5 fractions, 42 Gy in 5 fractions, or 32 Gy in 4 fractions. Dose conformity was calculated with three parameters: the conformity index (CI), the new conformity index (nCI) and the modified conformal index (mCOIN). A statistical analysis of the tumor control probability (TCP) was also calculated.Results: The CI and nCI of the CyberKnife(superscript ®) treatment planning system are all under 1.483. All the calculated TCP values were greater than 98.3%. We added the factors pertaining to the critical organ and obtained the mCOINs. The mCOIN values were listed to compare the quality of treatment plans.Conclusion: The conformity index value can be used to evaluate the quality of radiosurgery planning. The mCOIN values are also feasible to compare the plans.

AB - Purpose: This study was to evaluate the feasibility of dose conformity and tumor control probability calculated for CyberKnife(superscript ®) hypofractionated planning for prostate cancer.Materials and Methods: Six patients with early prostate cancer were included in this retrospective study. They received stereotactic hypofractionation radiotherapy by CyberKnife(superscript ®). The dose prescriptions were 37.5 Gy in 5 fractions, 42 Gy in 5 fractions, or 32 Gy in 4 fractions. Dose conformity was calculated with three parameters: the conformity index (CI), the new conformity index (nCI) and the modified conformal index (mCOIN). A statistical analysis of the tumor control probability (TCP) was also calculated.Results: The CI and nCI of the CyberKnife(superscript ®) treatment planning system are all under 1.483. All the calculated TCP values were greater than 98.3%. We added the factors pertaining to the critical organ and obtained the mCOINs. The mCOIN values were listed to compare the quality of treatment plans.Conclusion: The conformity index value can be used to evaluate the quality of radiosurgery planning. The mCOIN values are also feasible to compare the plans.

KW - Conformity index

KW - Tumor control probability

KW - Stereotactic radiosurgery

KW - CyberKnife

KW - 腫瘤包覆順型度

KW - 腫瘤控制機率模式

KW - 立體定位放射線手術

KW - 電腦刀

U2 - 10.6316/TRO/200815(4)301

DO - 10.6316/TRO/200815(4)301

M3 - Article

VL - 15

SP - 301

EP - 310

JO - 放射治療與腫瘤學

JF - 放射治療與腫瘤學

SN - 1023-988x

IS - 4

ER -