Evaluation of biomechanical properties of Expanded-Polytetrafluoroethylene™ soft tissue patch after dorsal implantation in the rat to mimic TMJ lateral reconstruction

Wen-FuThomas Lai, J. W. Stockstill, W. P. Deng, J. Bowley, J. G. Burch

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

Clinically, Gore-Tex Expanded-Polytetrafluoroethylene™ (E-PTFE™) has been used to reconstruct the lateral temporomandibular joint (TMJ) ligament. The purpose of this study was to assess changes in the biomechanical properties of implanted E-PTFE™ over time with respect to tissue infiltration. Ninety-six specimens of implants were divided into four groups. Group A was the experimental group. Thirty-six autoclave-sterilized specimens were subcutaneously implanted into the backs of 36 rats. The rats were randomly sacrificed at 2 (n = 12), 7 (n = 12) and 12 (n = 12) weeks. The implants were tested for mechanical properties including maximal stress, strain and Young's modulus of elasticity (E) using the servo-hydraulic material testing system (MTS). Group B was the in vitro control group. Thirty-six specimens were placed in tissue culture media at 37°C for a time period equivalent to the experimental group to simulate the effect of a moist, warm environment on biomechanical properties. Group C was the temperature and pressure control group. Twelve specimens were autoclave-sterilized to determine the changes of tensile strength under high temperature and pressure. Control group D (no treatment) was tested to determine the initial tensile strength. The results showed significantly larger maximal stress as well as an increase in E and smaller maximal strain in experimental group A than in control groups B, C and D. There was no significant difference among control groups B, C and D. Histological examination of implants at 12 weeks demonstrated that 0.2-0.3 mm of 1-mm thick implants were occupied by connective tissue from each side. It may be concluded that E-PTFE™ implants become stronger and less flexible after implantation in vivo.
原文英語
頁(從 - 到)257-266
頁數10
期刊Journal of Oral Rehabilitation
28
發行號3
出版狀態已發佈 - 三月 2001

指紋

Temporomandibular Joint
Polytetrafluoroethylene
Control Groups
Tensile Strength
Elastic Modulus
Materials Testing
Pressure
Temperature
Ligaments
Connective Tissue
Culture Media

ASJC Scopus subject areas

  • Dentistry(all)

引用此文

Evaluation of biomechanical properties of Expanded-Polytetrafluoroethylene™ soft tissue patch after dorsal implantation in the rat to mimic TMJ lateral reconstruction. / Lai, Wen-FuThomas; Stockstill, J. W.; Deng, W. P.; Bowley, J.; Burch, J. G.

於: Journal of Oral Rehabilitation, 卷 28, 編號 3, 03.2001, p. 257-266.

研究成果: 雜誌貢獻文章

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title = "Evaluation of biomechanical properties of Expanded-Polytetrafluoroethylene™ soft tissue patch after dorsal implantation in the rat to mimic TMJ lateral reconstruction",
abstract = "Clinically, Gore-Tex Expanded-Polytetrafluoroethylene™ (E-PTFE™) has been used to reconstruct the lateral temporomandibular joint (TMJ) ligament. The purpose of this study was to assess changes in the biomechanical properties of implanted E-PTFE™ over time with respect to tissue infiltration. Ninety-six specimens of implants were divided into four groups. Group A was the experimental group. Thirty-six autoclave-sterilized specimens were subcutaneously implanted into the backs of 36 rats. The rats were randomly sacrificed at 2 (n = 12), 7 (n = 12) and 12 (n = 12) weeks. The implants were tested for mechanical properties including maximal stress, strain and Young's modulus of elasticity (E) using the servo-hydraulic material testing system (MTS). Group B was the in vitro control group. Thirty-six specimens were placed in tissue culture media at 37°C for a time period equivalent to the experimental group to simulate the effect of a moist, warm environment on biomechanical properties. Group C was the temperature and pressure control group. Twelve specimens were autoclave-sterilized to determine the changes of tensile strength under high temperature and pressure. Control group D (no treatment) was tested to determine the initial tensile strength. The results showed significantly larger maximal stress as well as an increase in E and smaller maximal strain in experimental group A than in control groups B, C and D. There was no significant difference among control groups B, C and D. Histological examination of implants at 12 weeks demonstrated that 0.2-0.3 mm of 1-mm thick implants were occupied by connective tissue from each side. It may be concluded that E-PTFE™ implants become stronger and less flexible after implantation in vivo.",
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AU - Lai, Wen-FuThomas

AU - Stockstill, J. W.

AU - Deng, W. P.

AU - Bowley, J.

AU - Burch, J. G.

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N2 - Clinically, Gore-Tex Expanded-Polytetrafluoroethylene™ (E-PTFE™) has been used to reconstruct the lateral temporomandibular joint (TMJ) ligament. The purpose of this study was to assess changes in the biomechanical properties of implanted E-PTFE™ over time with respect to tissue infiltration. Ninety-six specimens of implants were divided into four groups. Group A was the experimental group. Thirty-six autoclave-sterilized specimens were subcutaneously implanted into the backs of 36 rats. The rats were randomly sacrificed at 2 (n = 12), 7 (n = 12) and 12 (n = 12) weeks. The implants were tested for mechanical properties including maximal stress, strain and Young's modulus of elasticity (E) using the servo-hydraulic material testing system (MTS). Group B was the in vitro control group. Thirty-six specimens were placed in tissue culture media at 37°C for a time period equivalent to the experimental group to simulate the effect of a moist, warm environment on biomechanical properties. Group C was the temperature and pressure control group. Twelve specimens were autoclave-sterilized to determine the changes of tensile strength under high temperature and pressure. Control group D (no treatment) was tested to determine the initial tensile strength. The results showed significantly larger maximal stress as well as an increase in E and smaller maximal strain in experimental group A than in control groups B, C and D. There was no significant difference among control groups B, C and D. Histological examination of implants at 12 weeks demonstrated that 0.2-0.3 mm of 1-mm thick implants were occupied by connective tissue from each side. It may be concluded that E-PTFE™ implants become stronger and less flexible after implantation in vivo.

AB - Clinically, Gore-Tex Expanded-Polytetrafluoroethylene™ (E-PTFE™) has been used to reconstruct the lateral temporomandibular joint (TMJ) ligament. The purpose of this study was to assess changes in the biomechanical properties of implanted E-PTFE™ over time with respect to tissue infiltration. Ninety-six specimens of implants were divided into four groups. Group A was the experimental group. Thirty-six autoclave-sterilized specimens were subcutaneously implanted into the backs of 36 rats. The rats were randomly sacrificed at 2 (n = 12), 7 (n = 12) and 12 (n = 12) weeks. The implants were tested for mechanical properties including maximal stress, strain and Young's modulus of elasticity (E) using the servo-hydraulic material testing system (MTS). Group B was the in vitro control group. Thirty-six specimens were placed in tissue culture media at 37°C for a time period equivalent to the experimental group to simulate the effect of a moist, warm environment on biomechanical properties. Group C was the temperature and pressure control group. Twelve specimens were autoclave-sterilized to determine the changes of tensile strength under high temperature and pressure. Control group D (no treatment) was tested to determine the initial tensile strength. The results showed significantly larger maximal stress as well as an increase in E and smaller maximal strain in experimental group A than in control groups B, C and D. There was no significant difference among control groups B, C and D. Histological examination of implants at 12 weeks demonstrated that 0.2-0.3 mm of 1-mm thick implants were occupied by connective tissue from each side. It may be concluded that E-PTFE™ implants become stronger and less flexible after implantation in vivo.

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