摘要
The ceramic form of calcium phosphate osteoconductive material such as hydroxyapatite is brittle, non-malleable and non-degradable, and these mechanical properties limit its clinical application in calvarium reconstruction. To improve these properties, we developed a malleable, biodegradable osteoconductive composite composed of tricalcium phosphate particles bound by a gelatin which is set by glutaraldehyde mediated cross-linking. The composite was implanted into a 15 X 15 mm full-thickness, calvarial defect in 20 rabbits for up to 3 months. Twelve rabbits were left unreconstructed as controls. Specimens were retrieved at 2 weeks, 1, 2 and 3 months. Five reconstructed and 3 unreconstructed rabbits were examined for each time period. The assessment included a series of post operative gross examinations, radiographs and histologic evaluations. We are able to demonstrate that this composite is (1) biocompatible, with little tissue reaction; (2) osteoconductive, with progressive growth of new bone into the calvarial defect; (3) biodegradable, with progressive replacement of the composite by new bone, acellular matrix and bone-like material. Replacement of this composite by new bone is postulated to occur by a combination of osteoconduction and biodegradation. These results indicate that further experimental research to combine this malleable, biodegradable, osteoconductive composite with an osteoinductive agent such as bone morphogenetic protein may generate new biomaterial for full-thickness calvarial defect reconstruction.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 44-50 |
| 頁數 | 7 |
| 期刊 | Materials Chemistry and Physics |
| 卷 | 55 |
| 發行號 | 1 |
| DOIs | |
| 出版狀態 | 已發佈 - 一月 1 1998 |
| 對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Materials Science(all)
- Condensed Matter Physics
引用此文
Evaluation of a novel malleable, biodegradable osteoconductive composite in a rabbit cranial defect model. / Chen, Tim Mo; Yao, Chun Hsu; Wang, Hsian-Jenn; Chou, Giuen Hsueng; Lee, Tze Wen; Lin, Feng Huei.
於: Materials Chemistry and Physics, 卷 55, 編號 1, 01.01.1998, p. 44-50.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Evaluation of a novel malleable, biodegradable osteoconductive composite in a rabbit cranial defect model
AU - Chen, Tim Mo
AU - Yao, Chun Hsu
AU - Wang, Hsian-Jenn
AU - Chou, Giuen Hsueng
AU - Lee, Tze Wen
AU - Lin, Feng Huei
PY - 1998/1/1
Y1 - 1998/1/1
N2 - The ceramic form of calcium phosphate osteoconductive material such as hydroxyapatite is brittle, non-malleable and non-degradable, and these mechanical properties limit its clinical application in calvarium reconstruction. To improve these properties, we developed a malleable, biodegradable osteoconductive composite composed of tricalcium phosphate particles bound by a gelatin which is set by glutaraldehyde mediated cross-linking. The composite was implanted into a 15 X 15 mm full-thickness, calvarial defect in 20 rabbits for up to 3 months. Twelve rabbits were left unreconstructed as controls. Specimens were retrieved at 2 weeks, 1, 2 and 3 months. Five reconstructed and 3 unreconstructed rabbits were examined for each time period. The assessment included a series of post operative gross examinations, radiographs and histologic evaluations. We are able to demonstrate that this composite is (1) biocompatible, with little tissue reaction; (2) osteoconductive, with progressive growth of new bone into the calvarial defect; (3) biodegradable, with progressive replacement of the composite by new bone, acellular matrix and bone-like material. Replacement of this composite by new bone is postulated to occur by a combination of osteoconduction and biodegradation. These results indicate that further experimental research to combine this malleable, biodegradable, osteoconductive composite with an osteoinductive agent such as bone morphogenetic protein may generate new biomaterial for full-thickness calvarial defect reconstruction.
AB - The ceramic form of calcium phosphate osteoconductive material such as hydroxyapatite is brittle, non-malleable and non-degradable, and these mechanical properties limit its clinical application in calvarium reconstruction. To improve these properties, we developed a malleable, biodegradable osteoconductive composite composed of tricalcium phosphate particles bound by a gelatin which is set by glutaraldehyde mediated cross-linking. The composite was implanted into a 15 X 15 mm full-thickness, calvarial defect in 20 rabbits for up to 3 months. Twelve rabbits were left unreconstructed as controls. Specimens were retrieved at 2 weeks, 1, 2 and 3 months. Five reconstructed and 3 unreconstructed rabbits were examined for each time period. The assessment included a series of post operative gross examinations, radiographs and histologic evaluations. We are able to demonstrate that this composite is (1) biocompatible, with little tissue reaction; (2) osteoconductive, with progressive growth of new bone into the calvarial defect; (3) biodegradable, with progressive replacement of the composite by new bone, acellular matrix and bone-like material. Replacement of this composite by new bone is postulated to occur by a combination of osteoconduction and biodegradation. These results indicate that further experimental research to combine this malleable, biodegradable, osteoconductive composite with an osteoinductive agent such as bone morphogenetic protein may generate new biomaterial for full-thickness calvarial defect reconstruction.
KW - Biodegradable composite
KW - Osteoconductive composite
KW - Rabbit cranial defect model
UR - http://www.scopus.com/inward/record.url?scp=0032143787&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032143787&partnerID=8YFLogxK
U2 - 10.1016/S0254-0584(98)00049-2
DO - 10.1016/S0254-0584(98)00049-2
M3 - Article
AN - SCOPUS:0032143787
VL - 55
SP - 44
EP - 50
JO - Materials Chemistry and Physics
JF - Materials Chemistry and Physics
SN - 0254-0584
IS - 1
ER -