Evaluation of a fibrin sealant free of bovine-derived components in an experimental vas anastomosis study

Olivier Vankemmel, Alexandre De La Taille, Thierry Burnouf, Jean Marc Rigot, Frank Duchene, Etienne Mazeman

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)

摘要

Objectives: The risk of transmission of bovine spongiform encephalopathy cannot be excluded from the use of bovine-derived products. The present study was undertaken to evaluate the performance of a new fibrin glue free of bovine-derived components in vas anastomosis and to compare this product to conventional vas anastomosis with fibrin glue. Methods: Bilateral delayed vas anastomosis was performed in 40 Sprague-Dawley rats. All animals underwent a fibrin glue-assisted vas anastomosis with three transmural sutures tied prior to fibrin glue application. The composition and preparation of fibrin glue was similar for all vas anastomoses except the fibrinolysis inhibitor component which was aprotinin (3,000 KUI/ml) in group 1 and tranexamic acid (10 mg/ml) in group 2. The animals (20 rats in both groups) were sacrificed 7 weeks postoperatively and evaluated for gross patency, presence of sperm granuloma and tensile strength measurements at the anastomosis site. Results: No difference was found between the 2 groups for all parameters evaluated whether a bovine-derived or a synthetic fibrinolysis inhibitor component was used. Conclusion: This study showed that tranexamic acid, a fibrinolysis inhibitor, can be substituted for conventional fibrin glue thereby avoiding the risks of bovine products. Copyright (C) 2000 S. Karger AG, Basel.
原文英語
頁(從 - 到)196-199
頁數4
期刊Urologia Internationalis
65
發行號4
出版狀態已發佈 - 2000
對外發佈Yes

ASJC Scopus subject areas

  • Urology

指紋 深入研究「Evaluation of a fibrin sealant free of bovine-derived components in an experimental vas anastomosis study」主題。共同形成了獨特的指紋。

引用此