Evaluating the performance of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 as the potential biomarkers of oral squamous cell carcinoma (OSCC)

Ching Yu Yen, Chien Yang Huang, Ming Feng Hou, Yi Hsin Yang, Chao Hsiang Chang, Hurng Wern Huang, Chung Ho Chen, Hsueh Wei Chang

研究成果: 雜誌貢獻文章同行評審

42 引文 斯高帕斯(Scopus)

摘要

Objectives: Some extracellular matrix genes as prognostic biomarkers for oral squamous cell carcinoma (OSCC) were evaluated. Methods: We investigated gene expression of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 in matched OSCC/margin tissues. Results: Areas under receiver-operating characteristic curves (AUCs) of relative mRNA expression of FN1, ITGA4, SDC2, and CD44 were 0.700, 0.677, 0.513, and 0.549, respectively. For tongue/mouth floor and edentulous ridge, AUC for FN1 and ITGA4 were 0.827 and 0.725 and sensitivities/specificities were 80%/84% and 88%/52%, respectively. Conclusion: FN1 and ITGA4 are potential OSCC biomarkers for tongue/mouth floor and edentulous ridge.
原文英語
頁(從 - 到)63-72
頁數10
期刊Biomarkers
18
發行號1
DOIs
出版狀態已發佈 - 二月 2013

ASJC Scopus subject areas

  • 生物化學
  • 臨床生物化學
  • 健康、毒理學和誘變

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