Estrogenic and anti-neutrophilic inflammatory phenanthrenes from Juncus effusus L.

Hao Chun Hu, Yi Hong Tsai, Yu Che Chuang, Kuei Hung Lai, Yu Ming Hsu, Tsong Long Hwang, Chih Chan Lin, Ferenc Fülöp, Yang Chang Wu, Szu Yin Yu, Yu Ting Kuo, Fang Rong Chang

研究成果: 雜誌貢獻文章同行評審

摘要

Juncus effusus L. (J. effusus) is a Traditional Chinese Medicine (TCM) that has long been used for dealing with gynaecological disorders, such as relieving insomnia, preventing tinnitus, reducing edema with diuretic effect. In our course of evidence-based medical research focused on this herb, one new phenanthrene, Junfusol B (2), together with seventeen known compounds were isolated and identified. All the structures of these compounds were elucidated by spectroscopic methods. The absolute stereochemistry of compounds 1 and 2 was further determined by comparing their calculated and experimental Electronic Circular Dichroism (ECD) spectra and optical rotation (OR) values. The isolates were evaluated for their estrogenic and anti-inflammatory activities which were considered as relevant etiological factors of insomnia, tinnitus and edema in the ancient TCM theory. The results revealed that most of the obtained phenanthrenes in this work were found exerting agonistic effects on estrogen receptor. This is the first report to declare the exact estrogen-regulating potential among this type of compounds from J. effusus. Moreover, phenanthrenes 3 − 7 exhibited significant inhibitions on superoxide anion generation and elastase release in fMLP/CB-induced human neutrophilic inflammation model. J. effusus may be developed as a complementary agent utilized in menopausal multiple syndromes.
原文英語
期刊Natural Product Research
DOIs
出版狀態接受/付印 - 2021

ASJC Scopus subject areas

  • 分析化學
  • 生物化學
  • 植物科學
  • 有機化學

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