Estrogen modulates sexually dimorphic contextual fear extinction in rats through estrogen receptor β

Yao Ju Chang, Chih Hao Yang, Ying Ching Liang, Che Ming Yeh, Chiung Chun Huang, Kuei Sen Hsu

研究成果: 雜誌貢獻文章同行評審

116 引文 斯高帕斯(Scopus)

摘要

Females and males are different in brain and behavior. These sex differences occur early during development due to a combination of genetic and hormonal factors and continue throughout the lifespan. Previous studies revealed that male rats exhibited significantly higher levels of contextual fear memory than female rats. However, it remains unknown whether a sex difference exists in the contextual fear extinction. To address this issue, male, normally cycling female, and ovariectomized (OVX) female Sprague-Dawley rats were subjected to contextual fear conditioning and extinction trials. Here we report that although male rats exhibited higher levels of freezing than cycling female rats after contextual fear conditioning, female rats subjected to conditioning in the proestrus and estrus stage exhibited an enhancement of fear extinction than male rats. An estrogen receptor (ER) b agonist diarylpropionitrile but not an ERa agonist propyl-pyrazole-triol administration also enhanced extinction of contextual fear in OVX female rats, suggesting that estrogen-mediated facilitation of extinction involves the activation of ERb. Intrahippocampal injection of estradiol or diarylpropionitrile before extinction training in OVX female rats remarkably reduced the levels of freezing response during extinction trials. In addition, the locomotion or anxiety state of female rats does not vary across the ovarian cycle. These results reveal a crucial role for estrogen in mediating sexually dimorphic contextual fear extinction, and that estrogen-mediated enhancement of fear extinction involves the activation of ERβ.
原文英語
頁(從 - 到)1142-1150
頁數9
期刊Hippocampus
19
發行號11
DOIs
出版狀態已發佈 - 十一月 2009
對外發佈

ASJC Scopus subject areas

  • 認知神經科學

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