Established HPLC fraction analysis to predict furanocoumarin-based herb-drug metabolic interactions

Ming Thau Sheu, Ying Ku Lin, Chia Hui Huang, Hsiu O. Ho

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

An attempt was made in this study to predict the potential for metabolic interactions of herbal extracts of drugs from their chromatographic profiles in reverse-phase high-performance liquid chromatography (RP-HPLC). Twenty-nine structurally related furanocoumarin compounds with known inhibitory interactions with cytochrome P450 3A (CYP3A), which is important for phase-I drug metabolism, were selected as a model system. A sigmoidal relationship was established between the CYP3A inhibitory potency (y) and the RP-HPLC total peak response unit (Ru, x) as y = 85.36 x (14.86 + x)-1 with a correlation coefficient of 0.63. The sigmoidal curve could be divided into three ranges designated low, medium and high risk that were used to indicate the relative inhibitory potency of the metabolic interactions of herbs or traditional Chinese herb medicines with CYP3A. These predictive classifications provide information or might be useful for 'risk category' decisions concerning herb-drug interactions.

原文英語
頁(從 - 到)865-877
頁數13
期刊Phytotherapy Research
26
發行號6
DOIs
出版狀態已發佈 - 六月 2012

ASJC Scopus subject areas

  • Pharmacology

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