Esomeprazole alone compared with esomeprazole plus aspirin for the treatment of aspirin-related peptic ulcers

Chun Peng Liu, Wen Chi Chen, Kwok Hung Lai, Guang Yuan Mar, Shyr Yi Lin, Luo Ping Ger, Ping I. Hsu

研究成果: 雜誌貢獻文章

10 引文 (Scopus)

摘要

BACKGROUND:Aspirin-related peptic ulcers are a common disorder. However, whether or not aspirin should be continued during treatment for aspirin-related ulcers remains unclear.AIMS:To compare esomeprazole alone with esomeprazole plus aspirin in the treatment of aspirin-related peptic ulcers and to investigate the independent factors associated with the failure of ulcer healing.METHODS:From January 2008 to July 2011, patients with aspirin-related peptic ulcers were randomized to receive esomeprazole (40 mg per day) alone or esomeprazole (40 mg per day) plus aspirin (100 mg per day) for 8 weeks. The subjects with Helicobacter pylori infection were treated with standard triple therapy. Follow-up endoscopy was carried out at the end of the 8th week. The primary end point was the healing of peptic ulcers.RESULTS:In all, 178 patients (89 receiving esomeprazole alone and 89 receiving esomeprazole plus aspirin) were enrolled and underwent follow-up endoscopy. The healing rate of ulcers by modified intention-to-treat analysis was 82.5% (95% confidence interval (CI), 74.2-90.8%) among patients treated with esomeprazole alone and 81.5% (95% CI, 73.0-90.0%) among patients treated with esomeprazole plus aspirin (difference, 1.0%; 95% CI, 11.2 to 12.6%). The per-protocol analysis yielded similar results (healing rate: 83.1% vs. 83.8%, respectively; difference, 0.7%; 95% CI, 11.2 to 12.6%). Multivariate analysis disclosed that use of steroids during treatment (odds ratio: 5.6; 95% CI, 1.1-27.7%) was the only independent factor associated with the failure of ulcer healing.CONCLUSIONS:The observed ulcer healing rates were comparable in the esomeprazole and esomeprazole-plus-aspirin groups, but the wide CIs do not rule out clinically meaningful differences of more than 10%.

原文英語
頁(從 - 到)1022-1029
頁數8
期刊American Journal of Gastroenterology
107
發行號7
DOIs
出版狀態已發佈 - 七月 2012

指紋

Esomeprazole
Peptic Ulcer
Aspirin
Ulcer
Confidence Intervals
Therapeutics
Endoscopy
Intention to Treat Analysis
Helicobacter Infections
Helicobacter pylori
Multivariate Analysis
Odds Ratio
Steroids

ASJC Scopus subject areas

  • Gastroenterology

引用此文

Esomeprazole alone compared with esomeprazole plus aspirin for the treatment of aspirin-related peptic ulcers. / Liu, Chun Peng; Chen, Wen Chi; Lai, Kwok Hung; Mar, Guang Yuan; Lin, Shyr Yi; Ger, Luo Ping; Hsu, Ping I.

於: American Journal of Gastroenterology, 卷 107, 編號 7, 07.2012, p. 1022-1029.

研究成果: 雜誌貢獻文章

Liu, Chun Peng ; Chen, Wen Chi ; Lai, Kwok Hung ; Mar, Guang Yuan ; Lin, Shyr Yi ; Ger, Luo Ping ; Hsu, Ping I. / Esomeprazole alone compared with esomeprazole plus aspirin for the treatment of aspirin-related peptic ulcers. 於: American Journal of Gastroenterology. 2012 ; 卷 107, 編號 7. 頁 1022-1029.
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title = "Esomeprazole alone compared with esomeprazole plus aspirin for the treatment of aspirin-related peptic ulcers",
abstract = "BACKGROUND:Aspirin-related peptic ulcers are a common disorder. However, whether or not aspirin should be continued during treatment for aspirin-related ulcers remains unclear.AIMS:To compare esomeprazole alone with esomeprazole plus aspirin in the treatment of aspirin-related peptic ulcers and to investigate the independent factors associated with the failure of ulcer healing.METHODS:From January 2008 to July 2011, patients with aspirin-related peptic ulcers were randomized to receive esomeprazole (40 mg per day) alone or esomeprazole (40 mg per day) plus aspirin (100 mg per day) for 8 weeks. The subjects with Helicobacter pylori infection were treated with standard triple therapy. Follow-up endoscopy was carried out at the end of the 8th week. The primary end point was the healing of peptic ulcers.RESULTS:In all, 178 patients (89 receiving esomeprazole alone and 89 receiving esomeprazole plus aspirin) were enrolled and underwent follow-up endoscopy. The healing rate of ulcers by modified intention-to-treat analysis was 82.5{\%} (95{\%} confidence interval (CI), 74.2-90.8{\%}) among patients treated with esomeprazole alone and 81.5{\%} (95{\%} CI, 73.0-90.0{\%}) among patients treated with esomeprazole plus aspirin (difference, 1.0{\%}; 95{\%} CI, 11.2 to 12.6{\%}). The per-protocol analysis yielded similar results (healing rate: 83.1{\%} vs. 83.8{\%}, respectively; difference, 0.7{\%}; 95{\%} CI, 11.2 to 12.6{\%}). Multivariate analysis disclosed that use of steroids during treatment (odds ratio: 5.6; 95{\%} CI, 1.1-27.7{\%}) was the only independent factor associated with the failure of ulcer healing.CONCLUSIONS:The observed ulcer healing rates were comparable in the esomeprazole and esomeprazole-plus-aspirin groups, but the wide CIs do not rule out clinically meaningful differences of more than 10{\%}.",
author = "Liu, {Chun Peng} and Chen, {Wen Chi} and Lai, {Kwok Hung} and Mar, {Guang Yuan} and Lin, {Shyr Yi} and Ger, {Luo Ping} and Hsu, {Ping I.}",
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T1 - Esomeprazole alone compared with esomeprazole plus aspirin for the treatment of aspirin-related peptic ulcers

AU - Liu, Chun Peng

AU - Chen, Wen Chi

AU - Lai, Kwok Hung

AU - Mar, Guang Yuan

AU - Lin, Shyr Yi

AU - Ger, Luo Ping

AU - Hsu, Ping I.

PY - 2012/7

Y1 - 2012/7

N2 - BACKGROUND:Aspirin-related peptic ulcers are a common disorder. However, whether or not aspirin should be continued during treatment for aspirin-related ulcers remains unclear.AIMS:To compare esomeprazole alone with esomeprazole plus aspirin in the treatment of aspirin-related peptic ulcers and to investigate the independent factors associated with the failure of ulcer healing.METHODS:From January 2008 to July 2011, patients with aspirin-related peptic ulcers were randomized to receive esomeprazole (40 mg per day) alone or esomeprazole (40 mg per day) plus aspirin (100 mg per day) for 8 weeks. The subjects with Helicobacter pylori infection were treated with standard triple therapy. Follow-up endoscopy was carried out at the end of the 8th week. The primary end point was the healing of peptic ulcers.RESULTS:In all, 178 patients (89 receiving esomeprazole alone and 89 receiving esomeprazole plus aspirin) were enrolled and underwent follow-up endoscopy. The healing rate of ulcers by modified intention-to-treat analysis was 82.5% (95% confidence interval (CI), 74.2-90.8%) among patients treated with esomeprazole alone and 81.5% (95% CI, 73.0-90.0%) among patients treated with esomeprazole plus aspirin (difference, 1.0%; 95% CI, 11.2 to 12.6%). The per-protocol analysis yielded similar results (healing rate: 83.1% vs. 83.8%, respectively; difference, 0.7%; 95% CI, 11.2 to 12.6%). Multivariate analysis disclosed that use of steroids during treatment (odds ratio: 5.6; 95% CI, 1.1-27.7%) was the only independent factor associated with the failure of ulcer healing.CONCLUSIONS:The observed ulcer healing rates were comparable in the esomeprazole and esomeprazole-plus-aspirin groups, but the wide CIs do not rule out clinically meaningful differences of more than 10%.

AB - BACKGROUND:Aspirin-related peptic ulcers are a common disorder. However, whether or not aspirin should be continued during treatment for aspirin-related ulcers remains unclear.AIMS:To compare esomeprazole alone with esomeprazole plus aspirin in the treatment of aspirin-related peptic ulcers and to investigate the independent factors associated with the failure of ulcer healing.METHODS:From January 2008 to July 2011, patients with aspirin-related peptic ulcers were randomized to receive esomeprazole (40 mg per day) alone or esomeprazole (40 mg per day) plus aspirin (100 mg per day) for 8 weeks. The subjects with Helicobacter pylori infection were treated with standard triple therapy. Follow-up endoscopy was carried out at the end of the 8th week. The primary end point was the healing of peptic ulcers.RESULTS:In all, 178 patients (89 receiving esomeprazole alone and 89 receiving esomeprazole plus aspirin) were enrolled and underwent follow-up endoscopy. The healing rate of ulcers by modified intention-to-treat analysis was 82.5% (95% confidence interval (CI), 74.2-90.8%) among patients treated with esomeprazole alone and 81.5% (95% CI, 73.0-90.0%) among patients treated with esomeprazole plus aspirin (difference, 1.0%; 95% CI, 11.2 to 12.6%). The per-protocol analysis yielded similar results (healing rate: 83.1% vs. 83.8%, respectively; difference, 0.7%; 95% CI, 11.2 to 12.6%). Multivariate analysis disclosed that use of steroids during treatment (odds ratio: 5.6; 95% CI, 1.1-27.7%) was the only independent factor associated with the failure of ulcer healing.CONCLUSIONS:The observed ulcer healing rates were comparable in the esomeprazole and esomeprazole-plus-aspirin groups, but the wide CIs do not rule out clinically meaningful differences of more than 10%.

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