Eruptive melanocytic nevi with malignant transformations and the connection to BRAF and p16 mutations

Ting Hua Yang, Kuo-Hsien Wang, Hsiou-Hsin Tsai, Jan-Show Chu

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

Eruptive melanocytic nevi (EMN) is a rare phenomenon with an unclear pathogenesis. Mutation on a molecular basis has been proposed, but insufficient data are available to confirm this hypothesis. Theoretically, the possibility of malignant transformation is high, but no previous definite cases had been reported. Herein, we report the first case of a patient with EMN in whom hypopharyngeal low-grade melanocytic malignancies were detected using a fibrolaryngoscope. BRAF activation and p16 mutations were discovered through real-time polymerase chain reaction and immunohistochemical staining on EMN tissue samples, respectively. The significance of these findings has yet to be determined.
原文英語
頁(從 - 到)30-33
頁數4
期刊Dermatologica Sinica
35
發行號1
DOIs
出版狀態已發佈 - 三月 1 2017

ASJC Scopus subject areas

  • Dermatology

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