Erlotinib response of EGFR-mutant gefitinib-resistant non-small-cell lung cancer

John Wen Cheng Chang, Chun Liang Chou, Shiu Feng Huang, Hung Ming Wang, Jia Juan Hsieh, Todd Hsu, Yun Chung Cheung

研究成果: 雜誌貢獻文章同行評審

34 引文 斯高帕斯(Scopus)

摘要

Purpose: Failure to gefitinib is generally believed to be associated with cross-resistance to other epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI). Here we report a case whose active EGFR-mutant NSCLC responded to erlotinib treatment. Patient and methods: Lung specimen was obtained during diagnostic procedures from a 41-year-old Taiwanese male smoker with adenocarcinoma. He received cisplatin-based chemotherapy following craniotomy to remove his brain metastasis. Tumor progressed in both lung and left adrenal gland. He underwent second-line docetaxel chemotherapy. Tumor progressed again 7 months later. He was subsequently treated with gefitinib 250 mg QD. Complete regression of the lung tumor and partial response of the left adrenal gland mass was achieved. Nine months later, the left lower lobe lung tumor and left adrenal gland tumor progressed. A lung biopsy from the left lower lobe disclosed an adenocarcinoma which harbored an in-frame deletion in exon 19 (heterozygous delE746-A750) of EGFR without a second mutation such as T790M in exon 20. Subsequent erlotinib 150 mg QD was administered. He experienced grade 1 skin rash, diarrhea and paronychia following erlotinib. Results: This patient achieved a partial response to erlotinib treatment. He remained on erlotinib for a total of 18 months until the left adrenal gland tumor progressed. Conclusions: This case demonstrated that NSCLC bearing in-frame deletion in exon 19 of EGFR may respond to erlotinib treatment following gefitinib failure.
原文英語
頁(從 - 到)414-417
頁數4
期刊Lung Cancer
58
發行號3
DOIs
出版狀態已發佈 - 十二月 1 2007
對外發佈

Keywords

  • EGFR mutation
  • Erlotinib
  • Gefitinib
  • NSCLC

ASJC Scopus subject areas

  • 腫瘤科
  • 肺和呼吸系統醫學
  • 癌症研究

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