摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 701-706 |
| 頁數 | 6 |
| 期刊 | Alcohol |
| 卷 | 48 |
| 發行號 | 7 |
| DOIs | |
| 出版狀態 | 已發佈 - 十一月 1 2014 |
指紋
ASJC Scopus subject areas
- Biochemistry
- Medicine(all)
- Behavioral Neuroscience
- Neurology
- Toxicology
- Health(social science)
引用此文
Epidermal growth factor improved alcohol-induced inflammation in rats. / Chen, Ya Ling; Peng, Hsiang Chi; Hsieh, Yi Ching; Yang, Suh-Ching.
於: Alcohol, 卷 48, 編號 7, 01.11.2014, p. 701-706.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Epidermal growth factor improved alcohol-induced inflammation in rats
AU - Chen, Ya Ling
AU - Peng, Hsiang Chi
AU - Hsieh, Yi Ching
AU - Yang, Suh-Ching
PY - 2014/11/1
Y1 - 2014/11/1
N2 - The purpose of this study was to investigate the effects of an epidermal growth factor (EGF) intervention on improving the inflammatory response of rats fed an ethanol-containing diet. Eight-week-old male Wistar rats were divided into ethanol (E) and control (C) groups. Rats in the E group were fed an ethanol liquid diet, while rats in the C group were pair-fed an isoenergetic diet without ethanol. After a 4-week ethanol-induction period, both the C and E group were respectively subdivided into 2 groups: a normal liquid diet without (C group, n=8) or with EGF supplementation (C+EGF, n=8), and the ethanol-containing diet without (E group, n=8) or with EGF supplementation (E+EGF group, n=8). The EGF (30μg/kg body weight/day) intervention period was carried out for the following 8 weeks. At the end of the experiment, activity of aspartate transaminase (AST) and alanine transaminase (ALT) and hepatic levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-10 in group E were significantly higher than those in group C. In addition, alterations in the gut microbiota profile were found in group E. In contrast, activity of AST and ALT and levels of TNF-α, IL-1β, and IL-6 in group E+EGF were significantly lower than those in group E. Significantly lower intestinal permeability and lower numbers of Escherichia coli in the fecal microbial culture were also found in group E+EGF. These results suggest that EGF improved the intestinal integrity by decreasing E.coli colonization and lowering intestinal permeability, which then ameliorated the inflammatory response under chronic ethanol exposure.
AB - The purpose of this study was to investigate the effects of an epidermal growth factor (EGF) intervention on improving the inflammatory response of rats fed an ethanol-containing diet. Eight-week-old male Wistar rats were divided into ethanol (E) and control (C) groups. Rats in the E group were fed an ethanol liquid diet, while rats in the C group were pair-fed an isoenergetic diet without ethanol. After a 4-week ethanol-induction period, both the C and E group were respectively subdivided into 2 groups: a normal liquid diet without (C group, n=8) or with EGF supplementation (C+EGF, n=8), and the ethanol-containing diet without (E group, n=8) or with EGF supplementation (E+EGF group, n=8). The EGF (30μg/kg body weight/day) intervention period was carried out for the following 8 weeks. At the end of the experiment, activity of aspartate transaminase (AST) and alanine transaminase (ALT) and hepatic levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-10 in group E were significantly higher than those in group C. In addition, alterations in the gut microbiota profile were found in group E. In contrast, activity of AST and ALT and levels of TNF-α, IL-1β, and IL-6 in group E+EGF were significantly lower than those in group E. Significantly lower intestinal permeability and lower numbers of Escherichia coli in the fecal microbial culture were also found in group E+EGF. These results suggest that EGF improved the intestinal integrity by decreasing E.coli colonization and lowering intestinal permeability, which then ameliorated the inflammatory response under chronic ethanol exposure.
KW - Alcoholic liver disease
KW - Epidermal growth factor
KW - Intestinal integrity
KW - Rats
UR - http://www.scopus.com/inward/record.url?scp=84908030659&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908030659&partnerID=8YFLogxK
U2 - 10.1016/j.alcohol.2014.07.008
DO - 10.1016/j.alcohol.2014.07.008
M3 - Article
C2 - 25174268
AN - SCOPUS:84908030659
VL - 48
SP - 701
EP - 706
JO - Alcohol
JF - Alcohol
SN - 0741-8329
IS - 7
ER -