Ephrin-Mediated cis-Attenuation of Eph Receptor Signaling Is Essential for Spinal Motor Axon Guidance

Tzu Jen Kao, Artur Kania

研究成果: 雜誌貢獻文章

95 引文 (Scopus)

摘要

Axon guidance receptors guide neuronal growth cones by binding in trans to axon guidance ligands in the developing nervous system. Some ligands are coexpressed in cis with their receptors, raising the question of the relative contribution of cis and trans interactions to axon guidance. Spinal motor axons use Eph receptors to select a limb trajectory in response to trans ephrins, while expressing ephrins in cis. We show that changes in motor neuron ephrin expression result in trajectory selection defects mirrored by changes in growth cone sensitivity to ephrins in vitro, arguing for ephrin cis-attenuation of Eph function. Furthermore, the relative contribution of trans-signaling and cis-attenuation is influenced by the subcellular distribution of ephrins to membrane patches containing Eph receptors. Thus, growth cone ephrins are essential for axon guidance in vivo and the balance between cis and trans modes of axon guidance ligand-receptor interaction contributes to the diversity of axon guidance signaling responses.
原文英語
頁(從 - 到)76-91
頁數16
期刊Neuron
71
發行號1
DOIs
出版狀態已發佈 - 七月 14 2011
對外發佈Yes

指紋

EphA1 Receptor
Ephrins
Growth Cones
Eph Family Receptors
Ligands
Motor Neurons
Axon Guidance
Nervous System
Axons
Extremities
Membranes

ASJC Scopus subject areas

  • Neuroscience(all)

引用此文

Ephrin-Mediated cis-Attenuation of Eph Receptor Signaling Is Essential for Spinal Motor Axon Guidance. / Kao, Tzu Jen; Kania, Artur.

於: Neuron, 卷 71, 編號 1, 14.07.2011, p. 76-91.

研究成果: 雜誌貢獻文章

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