12 引文 斯高帕斯(Scopus)

摘要

Background/Purpose: Cigarette smoking, exposure to secondhand smoke, and arsenic exposure are well known risk factors for developing urothelial carcinoma (UC). We investigated the combined effects of cigarette smoking, exposure to secondhand smoke, and the presence of urinary total arsenic on the risk of developing UC. Methods: We conducted a hospital-based, case-control study involving 261UC patients and 672 cancer-free control individuals between September 2002 and May 2009. Results: Individuals who had smoked 100 cigarettes in their lifetime (ever smokers) and had a high urinary total arsenic level, had increased risks of developing UC (3.20-fold and 6.45-fold greater), respectively, compared to individuals who were never smokers and had a low urinary total arsenic level. Individuals who had high urinary total arsenic levels and had been exposed to secondhand smoke, and individuals with high urinary arsenic levels who had not been exposed to secondhand smoke, had increased chances (2.71-fold and 5.00-fold greater, respectively) of developing UC, compared to individuals who were not exposed to secondhand smoke and had low urinary total arsenic levels. Ever smokers who had been exposed to secondhand smoke and had a high urinary total arsenic level had the greatest increased risk for developing UC (10.82-fold greater). Conclusion: Individuals in a Taiwanese population who smoked cigarettes, were exposed to secondhand smoke, and a high urinary total arsenic level, had a significant risk for developing UC.
原文英語
頁(從 - 到)554-560
頁數7
期刊Journal of the Formosan Medical Association = Taiwan yi zhi
112
發行號9
DOIs
出版狀態已發佈 - 九月 2013

ASJC Scopus subject areas

  • Medicine(all)

指紋 深入研究「Environmental tobacco smoke and arsenic methylation capacity are associated with urothelial carcinoma」主題。共同形成了獨特的指紋。

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