Enterovirus A71 neurologic complications and long-term sequelae

Luan Yin Chang, Hsiang Yuan Lin, Susan Shur Fen Gau, Chin Yu Lu, Shao Hsuan Hsia, Yhu Chering Huang, Li Min Huang, Tzou-Yien Lin

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)


During recent 20 years, enterovirus A71 (EV-A71) has emerged as a major concern among pediatric infectious diseases, particularly in the Asia-Pacific region. The clinical manifestations of EV-A71 include uncomplicated hand, foot, and mouth disease, herpanina or febrile illness and central nervous system (CNS) involvement such as aseptic meningitis, myoclonic jerk, polio-like syndrome, encephalitis, encephalomyelitis and cardiopulmonary failure due to severe rhombencephalitis. In follow-up studies of patients with EV-A 71 CNS infection, some still have hypoventilation and need tracheostomy with ventilator support, some have dysphagia and need nasogastric tube or gastrostomy feeding, some have limb weakness/astrophy, cerebellar dysfunction, neurodevelopmental delay, lower cognition, or attention deficiency hyperactivity disorder. Long term sequelae may be related to greater severity of CNS involvement or neuron damage, hypoxia and younger age of onset.

期刊Journal of Biomedical Science
出版狀態已發佈 - 八月 8 2019


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)


Chang, L. Y., Lin, H. Y., Gau, S. S. F., Lu, C. Y., Hsia, S. H., Huang, Y. C., Huang, L. M., & Lin, T-Y. (2019). Enterovirus A71 neurologic complications and long-term sequelae. Journal of Biomedical Science, 26(1), [57]. https://doi.org/10.1186/s12929-019-0552-7