Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2

Vijendra K. Singh, Sy Jye Christine Leu

研究成果: 雜誌貢獻文章同行評審

106 引文 斯高帕斯(Scopus)

摘要

Based upon an immunomodulatory role for Corticotropin-Releasing Factor (CRF), a low molecular weight neurohormone, we investigated the effect of CRF on the production of interleukin-1 (IL-1) and interleukin-2 (IL-2) activities of mononuclear cells isolated from the peripheral blood of healthy subjects. The production of both IL-1 and IL-2 was stimulated by a nanomolar concentration of CRF by itself. In addition, CRF augmented the production of IL-1 as induced by lipopolysaccharide and the production of IL-2 as induced by phytohemagglutinin. These results suggest that CRF modulates the function of the cells of the immune system presumably by acting as a blood-borne mediator of the neuroendocrine-immune pathways.

原文英語
頁(從 - 到)151-154
頁數4
期刊Neuroscience Letters
120
發行號2
DOIs
出版狀態已發佈 - 十二月 11 1990
對外發佈

ASJC Scopus subject areas

  • 神經科學 (全部)

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