Enhanced non-endocytotic uptake of mesoporous silica nanoparticles by shortening the peptide transporter arginine side Chain

Cheng Hsun Wu, Yi Ping Chen, Si Han Wu, Yann Hung, Chung Yuan Mou, Richard P. Cheng

研究成果: 雜誌貢獻文章

14 引文 (Scopus)

摘要

Mesoporous silica nanoparticles (MSNs) are multifunctional nanocarriers with potential biomedical applications. However, MSNs are frequently trapped in endosomes upon cellular uptake through endocytosis, requiring endosomal escape. Herein, enhanced nonendocytosis was observed for 300 nm MSNs by conjugating peptides with noncanonical arginine analogs.

原文英語
頁(從 - 到)12244-12248
頁數5
期刊ACS Applied Materials and Interfaces
5
發行號23
DOIs
出版狀態已發佈 - 十二月 11 2013
對外發佈Yes

指紋

Arginine
Silicon Dioxide
Nanoparticles
Peptides
Silica
Endosomes
Endocytosis
peptide permease

ASJC Scopus subject areas

  • Materials Science(all)
  • Medicine(all)

引用此文

Enhanced non-endocytotic uptake of mesoporous silica nanoparticles by shortening the peptide transporter arginine side Chain. / Wu, Cheng Hsun; Chen, Yi Ping; Wu, Si Han; Hung, Yann; Mou, Chung Yuan; Cheng, Richard P.

於: ACS Applied Materials and Interfaces, 卷 5, 編號 23, 11.12.2013, p. 12244-12248.

研究成果: 雜誌貢獻文章

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