Enhanced expression of transforming growth factor-β1 in inflammatory cells and secretory granules in Paneth cells in the small intestine of mice infected with Toxocara canis

Chia-Kwung Fan, C. C. Hung, Yun-Ho Lin, Ming Hsien Li, Kua Eyre Su

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)

摘要

The small intestine is the initial organ which Toxocara canis larvae invade. Information on intestinal pathological changes associated with transforming growth factor-β1 (TGF-β1) and secretory granules (SG) in Paneth cells (PCs) caused by T. canis is unclear. Mice orally inoculated with 250 T. canis infective eggs were evaluated by pathological and immunohistochemical assessments with a 294-day investigation. Pathologically, the inflammatory reactions with or without trapped larvae in the submucosa were observed only within the first 28 days post-infection (DPI), with inflammatory injury ranging from severe during 2 DPI to mild between 7 and 28 DPI. The crypts of Leiberkuhn were major larval penetration sites. Enhanced expression of SG in PCs appeared earlier than those of TGF-β1 in infiltrating cells. The significance of both effectors might be related to the host's defense against larval invasion in the intestinal phase of toxocaral infection.
原文英語
頁(從 - 到)397-404
頁數8
期刊Parasitology Research
94
發行號6
DOIs
出版狀態已發佈 - 十二月 2004

ASJC Scopus subject areas

  • Parasitology

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