Enhanced efficacy of chemotherapeutic drugs against colorectal cancer using ligand-decorated self-breakable agents

Ming Hsien Tsai, Cheng Liang Peng, Cheng Jung Yao, Ming Jium Shieh

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)

摘要

Several types of nano-sized anti-cancer agents that could increase the accumulation of drugs in tumor sites have been created and developed to enhance the efficacy of chemotherapeutic drugs in colon cancer treatment. In addition, to achieve the optimal cancer chemotherapeutic efficacy, nano-sized agents with specific functions were designed to efficiently kill cancer cells. The ideal nano-sized agent must be able to successfully release the drug and result in an increased cellular uptake of the chemotherapeutic drug. Our research team focused on two important functions, i.e. drug release and targeting functions, thus targeting functional micelles that were designed to possess disulfide bonds and entrapped much of the chemotherapeutic drug, 7-ethyl-10-hydroxy-camptothecin (SN38), which was created as a powerful candidate for an ideal anti-cancer drug for colon cancer treatment. In particular, self-breakable SN38-loaded micelles (SN/38 micelles), non-breakable SN38-loaded micelles (NB/38 micelles) and folate-decorated self-breakable SN38-loaded micelles (FSB/38 micelles) were prepared and tested on the designed agents. The results showed that the folate-decorated functional micelles with disulfide bonds could be an effective chemotherapeutic agent for colon cancer treatment.

原文英語
頁(從 - 到)92361-92370
頁數10
期刊RSC Advances
5
發行號112
DOIs
出版狀態已發佈 - 2015

ASJC Scopus subject areas

  • 化學 (全部)
  • 化學工程 (全部)

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