Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3

Ming Jen Hsu, Wan Wan Lin, Wei Chia Tsao, Yung Chi Chang, Tsui Ling Hsu, Allen W. Chiu, Chung Ching Chio, Shie Liang Hsieh

研究成果: 雜誌貢獻文章

40 引文 (Scopus)

摘要

Decoy receptor 3 (DcR3), a newly identified soluble protein belonging to the tumor necrosis factor receptor (TNFR) superfamily, is a receptor for Fas ligand (FasL), LIGHT and TL1A. It has been demonstrated that DcR3 is frequently overexpressed by malignant tumors arising from lung, gastrointestinal tract, neuronal glia and virus-associated leukemia. Recently, we demonstrated that DcR3 is able to modulate the differentiation and activation of dendritic cells (DCs), and that DcR3-treated DCs skew naive T cell differentiation towards a Th2 phenotype. In this study, we further demonstrate that DcR3 is able to induce actin reorganization and enhance the adhesion of monocytes and THP-1 cells by activating multiple signaling molecules, such as protein kinase C (PKC), phosphatidylinositol 3-kinase (PI3K), focal adhesion kinase (FAK) and Src kinases. This provides the first evidence that the soluble DcR3, like other immobilized members of TNFR superfamily, is able to trigger 'reverse signaling' to modulate cell function.

原文英語
頁(從 - 到)241-251
頁數11
期刊Experimental Cell Research
292
發行號2
DOIs
出版狀態已發佈 - 一月 15 2004
對外發佈Yes

指紋

Tumor Necrosis Factor Receptors
Dendritic Cells
Monocytes
Phosphatidylinositol 3-Kinase
Focal Adhesion Protein-Tyrosine Kinases
Fas Ligand Protein
src-Family Kinases
Neuroglia
Protein Kinase C
Gastrointestinal Tract
Actins
Cell Differentiation
Leukemia
Viruses
T-Lymphocytes
Phenotype
Light
Lung
Neoplasms
Proteins

ASJC Scopus subject areas

  • Cell Biology

引用此文

Hsu, M. J., Lin, W. W., Tsao, W. C., Chang, Y. C., Hsu, T. L., Chiu, A. W., ... Hsieh, S. L. (2004). Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3. Experimental Cell Research, 292(2), 241-251. https://doi.org/10.1016/j.yexcr.2003.09.019

Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3. / Hsu, Ming Jen; Lin, Wan Wan; Tsao, Wei Chia; Chang, Yung Chi; Hsu, Tsui Ling; Chiu, Allen W.; Chio, Chung Ching; Hsieh, Shie Liang.

於: Experimental Cell Research, 卷 292, 編號 2, 15.01.2004, p. 241-251.

研究成果: 雜誌貢獻文章

Hsu, MJ, Lin, WW, Tsao, WC, Chang, YC, Hsu, TL, Chiu, AW, Chio, CC & Hsieh, SL 2004, 'Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3', Experimental Cell Research, 卷 292, 編號 2, 頁 241-251. https://doi.org/10.1016/j.yexcr.2003.09.019
Hsu, Ming Jen ; Lin, Wan Wan ; Tsao, Wei Chia ; Chang, Yung Chi ; Hsu, Tsui Ling ; Chiu, Allen W. ; Chio, Chung Ching ; Hsieh, Shie Liang. / Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3. 於: Experimental Cell Research. 2004 ; 卷 292, 編號 2. 頁 241-251.
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