Endothelial progenitor cell dysfunction in polycystic ovary syndrome: Implications for the genesis of cardiovascular diseases

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

摘要

Polycystic ovary syndrome (PCOS), the most common endocrine disorder affecting women of reproductive age, is characterized by hyperandrogenism and insulin resistance. Women with PCOS have a higher risk for cardiovascular diseases (CVDs) and endothelial dysfunction. The mechanisms underlying these risks are unclear. Human peripheral blood contains circulating endothelial progenitor cells (EPCs) derived from bone marrow that have the ability to proliferate and differentiate into mature endothelial cells, which may contribute to vessel homeostasis and repair. PCOS is associated with insulin resistance, hyperinsulinemia, and dyslipidemia, which may result in EPC dysfunction. In this review, we summarize the potential mechanisms of EPC dysfunction in PCOS, which possibly result in a higher genesis of CVDs in PCOS-affected subjects.
原文英語
頁(從 - 到)208-213
頁數6
期刊International Journal of Fertility and Sterility
6
發行號4
出版狀態已發佈 - 一月 2013

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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