Endothelial progenitor cell dysfunction in cardiovascular diseases: Role of reactive oxygen species and inflammation

Chih Pei Lin, Feng Yen Lin, Po Hsun Huang, Yuh Lien Chen, Wen Chi Chen, Huey Yi Chen, Yu Chuen Huang, Wen Ling Liao, Huey Chun Huang, Po Len Liu, Yung Hsiang Chen

研究成果: 雜誌貢獻文章同行評審

58 引文 斯高帕斯(Scopus)

摘要

Endothelial progenitor cells (EPCs) move towards injured endothelium or inflamed tissues and incorporate into foci of neovascularisation, thereby improving blood flow and tissue repair. Patients with cardiovascular diseases have been shown to exhibit reduced EPC number and function. It has become increasingly apparent that these changes may be effected in response to enhanced oxidative stress, possibly as a result of systemic and localised inflammatory responses. The interplay between inflammation and oxidative stress affects the initiation, progression, and complications of cardiovascular diseases. Recent studies suggest that inflammation and oxidative stress modulate EPC bioactivity. Clinical medications with anti-inflammatory and antioxidant properties, such as statins, thiazolidinediones, angiotensin II receptor 1 blockers, and angiotensin-converting enzyme inhibitors, are currently administered to patients with cardiovascular diseases. These medications appear to exert beneficial effects on EPC biology. This review focuses on EPC biology and explores the links between oxidative stress, inflammation, and development of cardiovascular diseases.

原文英語
文章編號845037
期刊BioMed Research International
2013
DOIs
出版狀態已發佈 - 2013

ASJC Scopus subject areas

  • 生物化學、遺傳與分子生物學 (全部)
  • 免疫學與微生物學 (全部)
  • 醫藥 (全部)

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