Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region

Yung Tai Chen, Chih Chin Yu, Hsin Chih Yeh, Hsiang Ying Lee, Yuan Hong Jiang, Yu Khun Lee, Chia Hao Kuei, Chia Chang Wu, Chao Yuan Huang, Wei Yu Lin, Cheng Kuang Yang, Yao Chou Tsai

研究成果: 雜誌貢獻文章同行評審

摘要

Our aim was to analyze the clinical and survival differences among patients who underwent the two main treatment modalities, endoscopic ablation and radical nephroureterectomy. This study examined all patients who had undergone endoscopic management and RNU between Jul. 1988 and Mar. 2019 from the Taiwan UTUC registry. The inclusion criteria were low stage UTUC in RNU and all cases in endoscopic managed UTUC with a curative intent. The demographic and clinical characteristics were included for analysis. In total, 84 cases in the endoscopic group and 272 cases in the RNU group were enrolled for final analysis. The median follow-up period were 33.5 and 42.0 months in endoscopic and RNU group, respectively (p = 0.082). Comparison of Kaplan–Meier estimated survival curves between groups, the endoscopic group was associated with similar overall survival (OS), cancer specific survival (CSS), and intravesical recurrence free survival (IVRS) but demonstrated inferior disease free survival (DFS) (p = 0.188 for OS, p = 0.493 for CSS and p < 0.001 for DFS). Endoscopic management of UTUC was as safe as RNU in UTUC endemic region.

原文英語
文章編號4040
期刊Scientific Reports
11
發行號1
DOIs
出版狀態已發佈 - 十二月 2021

ASJC Scopus subject areas

  • General

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