Endogenous Opioid Receptor Genes and Alcohol Dependence among Taiwanese Han

El Wui Loh, Cathy S.J. Fann, Yuh Terng Chang, Ching Jui Chang, Andrew T.A. Cheng

研究成果: 雜誌貢獻文章同行評審

54 引文 斯高帕斯(Scopus)

摘要

Background: Nonselective opioid antagonists reduce alcohol consumption under various experimental situations, and several association studies have examined possible roles of opioid receptor mu (OPRM), delta (OPRD), and kappa (OPRK) genes in the development of alcohol dependence. Methods: We examined 20 single nucleotide polymorphisms (SNPs) across the OPRM, OPRD, and OPRK genes in 158 alcohol-dependent subjects and 149 controls. Differences in allele frequency and genotype distribution between case subjects and controls, as well as the deviation from Hardy-Weinberg equilibrium, were examined using Fisher's exact tests. Results: No significant difference in either allele or genotype frequency was found between case subjects and controls for each of the SNPs. Conclusions: Our findings do not support a possible role of the opioid receptor genes for the proclivity to alcohol dependence in the Taiwanese Han.
原文英語
頁(從 - 到)15-19
頁數5
期刊Alcoholism: Clinical and Experimental Research
28
發行號1
DOIs
出版狀態已發佈 - 一月 1 2004
對外發佈Yes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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