End stage renal disease is associated with development of dementia

Peir Haur Hung, Chih Ching Yeh, Chih Yen Hsiao, Pi Shan Sung, Chih Hsin Muo, Fung Chang Sung, Kuan Yu Hung, Kuen Jer Tsai

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

There is controversy regarding the extent of risk for dementia in patients with end stage renal disease (ESRD) who are undergoing hemodialysis (HD) or peritoneal dialysis (PD). We examined data from Taiwan's Longitudinal Health Insurance Database, and used Cox proportional hazard regression analysis to compare the development of dementia in 72,934 HD and PD patients with 72,934 matched controls from January 1, 1999 to December 31, 2010. The results indicate an increased risk for dementia overall in HD patients (adjusted hazard ratio [aHR] = 1.64, p < 0.0001) and PD patients (aHR = 2.21, p < 0.0001). HD and PD patients also had significantly greater aHRs for vascular dementia (VaD) and unspecified dementia (UnD), but only HD patients had a significantly greater aHR for Alzheimer's disease (AD). Further research is needed to confirm whether management of ESRD with PD can reduce the incidence of AD, and to identify the mechanisms by which ESRD increases the risk of dementia.
原文英語
頁(從 - 到)107348-107355
頁數8
期刊Oncotarget
8
發行號64
DOIs
出版狀態已發佈 - 一月 1 2017

指紋

Chronic Kidney Failure
Peritoneal Dialysis
Dementia
Renal Dialysis
Alzheimer Disease
Vascular Dementia
Health Insurance
Taiwan
Regression Analysis
Databases
Incidence
Research

ASJC Scopus subject areas

  • Oncology

引用此文

Hung, P. H., Yeh, C. C., Hsiao, C. Y., Sung, P. S., Muo, C. H., Sung, F. C., ... Tsai, K. J. (2017). End stage renal disease is associated with development of dementia. Oncotarget, 8(64), 107348-107355. https://doi.org/10.18632/oncotarget.22458

End stage renal disease is associated with development of dementia. / Hung, Peir Haur; Yeh, Chih Ching; Hsiao, Chih Yen; Sung, Pi Shan; Muo, Chih Hsin; Sung, Fung Chang; Hung, Kuan Yu; Tsai, Kuen Jer.

於: Oncotarget, 卷 8, 編號 64, 01.01.2017, p. 107348-107355.

研究成果: 雜誌貢獻文章

Hung, PH, Yeh, CC, Hsiao, CY, Sung, PS, Muo, CH, Sung, FC, Hung, KY & Tsai, KJ 2017, 'End stage renal disease is associated with development of dementia', Oncotarget, 卷 8, 編號 64, 頁 107348-107355. https://doi.org/10.18632/oncotarget.22458
Hung PH, Yeh CC, Hsiao CY, Sung PS, Muo CH, Sung FC 等. End stage renal disease is associated with development of dementia. Oncotarget. 2017 1月 1;8(64):107348-107355. https://doi.org/10.18632/oncotarget.22458
Hung, Peir Haur ; Yeh, Chih Ching ; Hsiao, Chih Yen ; Sung, Pi Shan ; Muo, Chih Hsin ; Sung, Fung Chang ; Hung, Kuan Yu ; Tsai, Kuen Jer. / End stage renal disease is associated with development of dementia. 於: Oncotarget. 2017 ; 卷 8, 編號 64. 頁 107348-107355.
@article{7b1c7a55f1a64b20af6ae42bf3fbdd8b,
title = "End stage renal disease is associated with development of dementia",
abstract = "There is controversy regarding the extent of risk for dementia in patients with end stage renal disease (ESRD) who are undergoing hemodialysis (HD) or peritoneal dialysis (PD). We examined data from Taiwan's Longitudinal Health Insurance Database, and used Cox proportional hazard regression analysis to compare the development of dementia in 72,934 HD and PD patients with 72,934 matched controls from January 1, 1999 to December 31, 2010. The results indicate an increased risk for dementia overall in HD patients (adjusted hazard ratio [aHR] = 1.64, p < 0.0001) and PD patients (aHR = 2.21, p < 0.0001). HD and PD patients also had significantly greater aHRs for vascular dementia (VaD) and unspecified dementia (UnD), but only HD patients had a significantly greater aHR for Alzheimer's disease (AD). Further research is needed to confirm whether management of ESRD with PD can reduce the incidence of AD, and to identify the mechanisms by which ESRD increases the risk of dementia.",
keywords = "Alzheimer's disease, Dementia, End stage renal disease, Gerotarget, Hemodialysis, Peritoneal dialysis",
author = "Hung, {Peir Haur} and Yeh, {Chih Ching} and Hsiao, {Chih Yen} and Sung, {Pi Shan} and Muo, {Chih Hsin} and Sung, {Fung Chang} and Hung, {Kuan Yu} and Tsai, {Kuen Jer}",
year = "2017",
month = "1",
day = "1",
doi = "10.18632/oncotarget.22458",
language = "English",
volume = "8",
pages = "107348--107355",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals LLC",
number = "64",

}

TY - JOUR

T1 - End stage renal disease is associated with development of dementia

AU - Hung, Peir Haur

AU - Yeh, Chih Ching

AU - Hsiao, Chih Yen

AU - Sung, Pi Shan

AU - Muo, Chih Hsin

AU - Sung, Fung Chang

AU - Hung, Kuan Yu

AU - Tsai, Kuen Jer

PY - 2017/1/1

Y1 - 2017/1/1

N2 - There is controversy regarding the extent of risk for dementia in patients with end stage renal disease (ESRD) who are undergoing hemodialysis (HD) or peritoneal dialysis (PD). We examined data from Taiwan's Longitudinal Health Insurance Database, and used Cox proportional hazard regression analysis to compare the development of dementia in 72,934 HD and PD patients with 72,934 matched controls from January 1, 1999 to December 31, 2010. The results indicate an increased risk for dementia overall in HD patients (adjusted hazard ratio [aHR] = 1.64, p < 0.0001) and PD patients (aHR = 2.21, p < 0.0001). HD and PD patients also had significantly greater aHRs for vascular dementia (VaD) and unspecified dementia (UnD), but only HD patients had a significantly greater aHR for Alzheimer's disease (AD). Further research is needed to confirm whether management of ESRD with PD can reduce the incidence of AD, and to identify the mechanisms by which ESRD increases the risk of dementia.

AB - There is controversy regarding the extent of risk for dementia in patients with end stage renal disease (ESRD) who are undergoing hemodialysis (HD) or peritoneal dialysis (PD). We examined data from Taiwan's Longitudinal Health Insurance Database, and used Cox proportional hazard regression analysis to compare the development of dementia in 72,934 HD and PD patients with 72,934 matched controls from January 1, 1999 to December 31, 2010. The results indicate an increased risk for dementia overall in HD patients (adjusted hazard ratio [aHR] = 1.64, p < 0.0001) and PD patients (aHR = 2.21, p < 0.0001). HD and PD patients also had significantly greater aHRs for vascular dementia (VaD) and unspecified dementia (UnD), but only HD patients had a significantly greater aHR for Alzheimer's disease (AD). Further research is needed to confirm whether management of ESRD with PD can reduce the incidence of AD, and to identify the mechanisms by which ESRD increases the risk of dementia.

KW - Alzheimer's disease

KW - Dementia

KW - End stage renal disease

KW - Gerotarget

KW - Hemodialysis

KW - Peritoneal dialysis

UR - http://www.scopus.com/inward/record.url?scp=85037341187&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85037341187&partnerID=8YFLogxK

U2 - 10.18632/oncotarget.22458

DO - 10.18632/oncotarget.22458

M3 - Article

AN - SCOPUS:85037341187

VL - 8

SP - 107348

EP - 107355

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 64

ER -