Enabling Technologies for Personalized and Precision Medicine

Dean Ho, Stephen R. Quake, Edward R.B. McCabe, Wee Joo Chng, Edward K. Chow, Xianting Ding, Bruce D. Gelb, Geoffrey S. Ginsburg, Jason Hassenstab, Chih Ming Ho, William C. Mobley, Garry P. Nolan, Steven T. Rosen, Patrick Tan, Yun Yen, Ali Zarrinpar

研究成果: 雜誌貢獻回顧型文獻同行評審

63 引文 斯高帕斯(Scopus)

摘要

Individualizing patient treatment is a core objective of the medical field. Reaching this objective has been elusive owing to the complex set of factors contributing to both disease and health; many factors, from genes to proteins, remain unknown in their role in human physiology. Accurately diagnosing, monitoring, and treating disorders requires advances in biomarker discovery, the subsequent development of accurate signatures that correspond with dynamic disease states, as well as therapeutic interventions that can be continuously optimized and modulated for dose and drug selection. This work highlights key breakthroughs in the development of enabling technologies that further the goal of personalized and precision medicine, and remaining challenges that, when addressed, may forge unprecedented capabilities in realizing truly individualized patient care.
原文英語
頁(從 - 到)497-518
頁數22
期刊Trends in Biotechnology
38
發行號5
DOIs
出版狀態已發佈 - 5月 2020

ASJC Scopus subject areas

  • 生物技術
  • 生物工程

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