Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene

Hsueh Yueh Su; Shur Hueih Cherng; Chien Chung Chen; Huei Lee

doi:10.1016/0027-5107(95)00045-K

Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene

Hsueh Yueh Su, Shur Hueih Cherng, Chien Chung Chen, Huei Lee

研究成果: 雜誌貢獻 › 文章

43 引文斯高帕斯（Scopus）

摘要

Polygonum cuspidatum S. (PC) is frequently used as a laxative and an anticancer drug in Chinese medicine. The inhibitory effect of this herb and its component, emodin, on the direct-acting mutagenicity of 1-nitropyrene (1-NP) was examined using the Ames/microsomal test with Salmonella typhimurium TA98 and the genotoxicity of 1-NP was evaluated using the SOS chromotest with E. coli PQ37. Emodin and water extracts of PC markedly decreased the mutagenicity of 1-NP in a dose-dependent manner in both assay systems. Furthermore, emodin and the extracts of PC significantly inhibited the formation of 1-NP DNA adducts in S. typhimurium TA98 in the 32P-postlabeling study. The results suggest that PC extracts and emodin act as blocking and/or suppressing agents to reduce the direct-acting mutagenicity of 1-NP.

原文	英語
頁（從 - 到）	205-212
頁數	8
期刊	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
卷	329
發行號	2
DOIs	https://doi.org/10.1016/0027-5107(95)00045-K
出版狀態	已發佈 - 1995
對外發佈	Yes

指紋

ASJC Scopus subject areas

Genetics
Molecular Biology
Health, Toxicology and Mutagenesis

引用此

Su, H. Y., Cherng, S. H., Chen, C. C., & Lee, H. (1995). Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 329(2), 205-212. https://doi.org/10.1016/0027-5107(95)00045-K

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title = "Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene",

abstract = "Polygonum cuspidatum S. (PC) is frequently used as a laxative and an anticancer drug in Chinese medicine. The inhibitory effect of this herb and its component, emodin, on the direct-acting mutagenicity of 1-nitropyrene (1-NP) was examined using the Ames/microsomal test with Salmonella typhimurium TA98 and the genotoxicity of 1-NP was evaluated using the SOS chromotest with E. coli PQ37. Emodin and water extracts of PC markedly decreased the mutagenicity of 1-NP in a dose-dependent manner in both assay systems. Furthermore, emodin and the extracts of PC significantly inhibited the formation of 1-NP DNA adducts in S. typhimurium TA98 in the 32P-postlabeling study. The results suggest that PC extracts and emodin act as blocking and/or suppressing agents to reduce the direct-acting mutagenicity of 1-NP.",

keywords = "1-Nitropyrene, DNA adduct, Mutagenicity, Emodin, Polygonum cuspidatum S.",

author = "Su, {Hsueh Yueh} and Cherng, {Shur Hueih} and Chen, {Chien Chung} and Huei Lee",

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T1 - Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene

AU - Su, Hsueh Yueh

AU - Cherng, Shur Hueih

AU - Chen, Chien Chung

AU - Lee, Huei

PY - 1995

Y1 - 1995

N2 - Polygonum cuspidatum S. (PC) is frequently used as a laxative and an anticancer drug in Chinese medicine. The inhibitory effect of this herb and its component, emodin, on the direct-acting mutagenicity of 1-nitropyrene (1-NP) was examined using the Ames/microsomal test with Salmonella typhimurium TA98 and the genotoxicity of 1-NP was evaluated using the SOS chromotest with E. coli PQ37. Emodin and water extracts of PC markedly decreased the mutagenicity of 1-NP in a dose-dependent manner in both assay systems. Furthermore, emodin and the extracts of PC significantly inhibited the formation of 1-NP DNA adducts in S. typhimurium TA98 in the 32P-postlabeling study. The results suggest that PC extracts and emodin act as blocking and/or suppressing agents to reduce the direct-acting mutagenicity of 1-NP.

AB - Polygonum cuspidatum S. (PC) is frequently used as a laxative and an anticancer drug in Chinese medicine. The inhibitory effect of this herb and its component, emodin, on the direct-acting mutagenicity of 1-nitropyrene (1-NP) was examined using the Ames/microsomal test with Salmonella typhimurium TA98 and the genotoxicity of 1-NP was evaluated using the SOS chromotest with E. coli PQ37. Emodin and water extracts of PC markedly decreased the mutagenicity of 1-NP in a dose-dependent manner in both assay systems. Furthermore, emodin and the extracts of PC significantly inhibited the formation of 1-NP DNA adducts in S. typhimurium TA98 in the 32P-postlabeling study. The results suggest that PC extracts and emodin act as blocking and/or suppressing agents to reduce the direct-acting mutagenicity of 1-NP.

KW - 1-Nitropyrene

KW - DNA adduct, Mutagenicity

KW - Emodin

KW - Polygonum cuspidatum S.

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JO - Mutation Research

JF - Mutation Research

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存取文件

10.1016/0027-5107(95)00045-K