摘要
Polygonum cuspidatum S. (PC) is frequently used as a laxative and an anticancer drug in Chinese medicine. The inhibitory effect of this herb and its component, emodin, on the direct-acting mutagenicity of 1-nitropyrene (1-NP) was examined using the Ames/microsomal test with Salmonella typhimurium TA98 and the genotoxicity of 1-NP was evaluated using the SOS chromotest with E. coli PQ37. Emodin and water extracts of PC markedly decreased the mutagenicity of 1-NP in a dose-dependent manner in both assay systems. Furthermore, emodin and the extracts of PC significantly inhibited the formation of 1-NP DNA adducts in S. typhimurium TA98 in the 32P-postlabeling study. The results suggest that PC extracts and emodin act as blocking and/or suppressing agents to reduce the direct-acting mutagenicity of 1-NP.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 205-212 |
| 頁數 | 8 |
| 期刊 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis |
| 卷 | 329 |
| 發行號 | 2 |
| DOIs | |
| 出版狀態 | 已發佈 - 1995 |
| 對外發佈 | 是 |
ASJC Scopus subject areas
- 遺傳學
- 分子生物學
- 健康、毒理學和誘變