Polygonum cuspidatum S. (PC) is frequently used as a laxative and an anticancer drug in Chinese medicine. The inhibitory effect of this herb and its component, emodin, on the direct-acting mutagenicity of 1-nitropyrene (1-NP) was examined using the Ames/microsomal test with Salmonella typhimurium TA98 and the genotoxicity of 1-NP was evaluated using the SOS chromotest with E. coli PQ37. Emodin and water extracts of PC markedly decreased the mutagenicity of 1-NP in a dose-dependent manner in both assay systems. Furthermore, emodin and the extracts of PC significantly inhibited the formation of 1-NP DNA adducts in S. typhimurium TA98 in the 32P-postlabeling study. The results suggest that PC extracts and emodin act as blocking and/or suppressing agents to reduce the direct-acting mutagenicity of 1-NP.
|頁（從 - 到）||205-212|
|期刊||Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis|
|出版狀態||已發佈 - 1995|
ASJC Scopus subject areas
- Molecular Biology
- Health, Toxicology and Mutagenesis
Su, H. Y., Cherng, S. H., Chen, C. C., & Lee, H. (1995). Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 329(2), 205-212. https://doi.org/10.1016/0027-5107(95)00045-K