Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene

Hsueh Yueh Su, Shur Hueih Cherng, Chien Chung Chen, Huei Lee

研究成果: 雜誌貢獻文章

43 引文 斯高帕斯(Scopus)

摘要

Polygonum cuspidatum S. (PC) is frequently used as a laxative and an anticancer drug in Chinese medicine. The inhibitory effect of this herb and its component, emodin, on the direct-acting mutagenicity of 1-nitropyrene (1-NP) was examined using the Ames/microsomal test with Salmonella typhimurium TA98 and the genotoxicity of 1-NP was evaluated using the SOS chromotest with E. coli PQ37. Emodin and water extracts of PC markedly decreased the mutagenicity of 1-NP in a dose-dependent manner in both assay systems. Furthermore, emodin and the extracts of PC significantly inhibited the formation of 1-NP DNA adducts in S. typhimurium TA98 in the 32P-postlabeling study. The results suggest that PC extracts and emodin act as blocking and/or suppressing agents to reduce the direct-acting mutagenicity of 1-NP.
原文英語
頁(從 - 到)205-212
頁數8
期刊Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
329
發行號2
DOIs
出版狀態已發佈 - 1995
對外發佈Yes

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Health, Toxicology and Mutagenesis

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