Emergence of KPC new variants (KPC-16 and KPC-17) and ongoing outbreak in southern Taiwan

W. L. Yu; M. F. Lee; H. J. Tang; M. C. Chang; J. Walther-Rasmussen; Y. C. Chuang

doi:10.1016/j.cmi.2014.11.030

Emergence of KPC new variants (KPC-16 and KPC-17) and ongoing outbreak in southern Taiwan

W. L. Yu, M. F. Lee, H. J. Tang, M. C. Chang, J. Walther-Rasmussen, Y. C. Chuang

研究成果: 雜誌貢獻 › 文章 › 同行評審

12 引文斯高帕斯（Scopus）

摘要

We first describe two novel variants of blaKPC, blaKPC-16 and blaKPC-17, which were identified in three Klebsiella pneumoniae isolates from a patient in Taiwan. KPC-16 and KPC-17 differed from KPC-2 by two (P202S and F207L) and a single (F207L) amino acid substitutions, respectively. All three isolates with identical pulsotype belonged to sequence type 11. The MICs of the three isolates for colistin and tigecycline were 0.5 μg/mL and 2 μg/mL, respectively. Moreover, an outbreak of at least 39 blaKPC-17-containing K. pneumoniae isolates is ongoing in southern Taiwan in 2014. Physicians should know that blaKPC-17-containing isolates can substantially threaten public health.

原文	英語
期刊	Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
卷	21
發行號	4
DOIs	https://doi.org/10.1016/j.cmi.2014.11.030
出版狀態	已發佈 - 4月 1 2015

ASJC Scopus subject areas

微生物學（醫學）
傳染性疾病

UN SDG

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10.1016/j.cmi.2014.11.030

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Yu, W. L., Lee, M. F., Tang, H. J., Chang, M. C., Walther-Rasmussen, J., & Chuang, Y. C. (2015). Emergence of KPC new variants (KPC-16 and KPC-17) and ongoing outbreak in southern Taiwan. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 21(4). https://doi.org/10.1016/j.cmi.2014.11.030

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title = "Emergence of KPC new variants (KPC-16 and KPC-17) and ongoing outbreak in southern Taiwan",

abstract = "We first describe two novel variants of blaKPC, blaKPC-16 and blaKPC-17, which were identified in three Klebsiella pneumoniae isolates from a patient in Taiwan. KPC-16 and KPC-17 differed from KPC-2 by two (P202S and F207L) and a single (F207L) amino acid substitutions, respectively. All three isolates with identical pulsotype belonged to sequence type 11. The MICs of the three isolates for colistin and tigecycline were 0.5 μg/mL and 2 μg/mL, respectively. Moreover, an outbreak of at least 39 blaKPC-17-containing K. pneumoniae isolates is ongoing in southern Taiwan in 2014. Physicians should know that blaKPC-17-containing isolates can substantially threaten public health.",

keywords = "Carbapenemase, Klebsiella pneumoniae, KPC-16, KPC-17, KPC-2",

author = "Yu, {W. L.} and Lee, {M. F.} and Tang, {H. J.} and Chang, {M. C.} and J. Walther-Rasmussen and Chuang, {Y. C.}",

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T1 - Emergence of KPC new variants (KPC-16 and KPC-17) and ongoing outbreak in southern Taiwan

AU - Yu, W. L.

AU - Lee, M. F.

AU - Tang, H. J.

AU - Chang, M. C.

AU - Walther-Rasmussen, J.

AU - Chuang, Y. C.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - We first describe two novel variants of blaKPC, blaKPC-16 and blaKPC-17, which were identified in three Klebsiella pneumoniae isolates from a patient in Taiwan. KPC-16 and KPC-17 differed from KPC-2 by two (P202S and F207L) and a single (F207L) amino acid substitutions, respectively. All three isolates with identical pulsotype belonged to sequence type 11. The MICs of the three isolates for colistin and tigecycline were 0.5 μg/mL and 2 μg/mL, respectively. Moreover, an outbreak of at least 39 blaKPC-17-containing K. pneumoniae isolates is ongoing in southern Taiwan in 2014. Physicians should know that blaKPC-17-containing isolates can substantially threaten public health.

AB - We first describe two novel variants of blaKPC, blaKPC-16 and blaKPC-17, which were identified in three Klebsiella pneumoniae isolates from a patient in Taiwan. KPC-16 and KPC-17 differed from KPC-2 by two (P202S and F207L) and a single (F207L) amino acid substitutions, respectively. All three isolates with identical pulsotype belonged to sequence type 11. The MICs of the three isolates for colistin and tigecycline were 0.5 μg/mL and 2 μg/mL, respectively. Moreover, an outbreak of at least 39 blaKPC-17-containing K. pneumoniae isolates is ongoing in southern Taiwan in 2014. Physicians should know that blaKPC-17-containing isolates can substantially threaten public health.

KW - Carbapenemase

KW - Klebsiella pneumoniae

KW - KPC-16

KW - KPC-17

KW - KPC-2

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VL - 21

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 4

ER -

Emergence of KPC new variants (KPC-16 and KPC-17) and ongoing outbreak in southern Taiwan

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