Embryo implantation in in vitro fertilization and intracytoplasmic sperm injection: Impact of cleavage status, morphology grade, and number of embryos transferred

Ming I. Hsu, Jake Mayer, Michael Aronshon, Susan Lanzendorf, Suheil Muasher, Paul Kolm, Sergio Oehninger

研究成果: 雜誌貢獻文章同行評審

89 引文 斯高帕斯(Scopus)

摘要

Objective: The aims of this study were to compare preimplantation embryo quality in intracytoplasmic sperm injection (ICSI) with standard IVF and to examine the impact of age and number and quality of embryos transferred on implantation and pregnancy. Design: Retrospective, controlled clinical study. Setting: Academic tertiary center. Patient(s): We examined 211 consecutive couples undergoing ICSI who were matched with 211 couples undergoing IVF therapy during the same time frame. Intervention(s): In vitro embryo culture. Main Outcome Measure(s): Day 3 embryo quality as judged by the number of blastomeres and morphology scoring. Result(s): Patients undergoing ICSI had a significantly reduced number of embryos with good morphology and cleavage compared with IVF cases. Nevertheless, pregnancy and abortion rates were similar when adjusted by age and number of embryos transferred. Average cleavage status and age were significant predictors of implantation. Women of advanced age had significantly lower embryo cleavage and implantation rates. Conclusion(s): [1] The cleaving status of day 3 embryos is a valuable, although limited, indicator of implantation outcome. [2] In vitro fertilization-derived embryos had better cleavage rates and morphology scores than ICSI-derived embryos; however, the implantation potential was similar for both groups. [3] The age-related decline in implantation rate was associated with impaired embryo growth rates.

原文英語
頁(從 - 到)679-685
頁數7
期刊Fertility and Sterility
72
發行號4
DOIs
出版狀態已發佈 - 10月 1999
對外發佈

ASJC Scopus subject areas

  • 生殖醫學
  • 婦產科

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