Elevated uric acid level as a significant predictor of chronic kidney disease

a cohort study with repeated measurements

Yu Ching Chou, Jen Chun Kuan, Tsan Yang, Wan Yun Chou, Po Chien Hsieh, Chyi-Huey Bai, San Lin You, Chien Hua Chen, Cheng Yu Wei, Chien An Sun

研究成果: 雜誌貢獻文章

11 引文 (Scopus)

摘要

Background: Cohort studies evaluating increased serum uric acid (SUA) level as a chronic kidney disease (CKD) risk factor have yielded variable results. We aimed to assess the association between the pattern of longitudinal changes in SUA and incident CKD [estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2]. Methods: A population-based cohort study was conducted on 3,605 participants who were followed prospectively for a mean of 5.18 years. The longitudinal changes in SUA were categorized into three subgroups: persistently low, fluctuated (reduced or elevated), and persistently high. The primary outcome of interest was the development of CKD at a follow-up examination. Cox proportional hazards analysis was used to test the hypothesis. Results: After adjustment for potential confounders, participants with fluctuated SUA with progressively elevated level and persistently high SUA level had significantly higher risk of developing CKD compared to subjects with persistently low SUA level: adjusted hazard ratio (95 % confidence interval) was 2.05 (1.24–3.38) vs. 1.90 (1.34–2.71). This longitudinal relationship was independent of sex, age, body mass index, and hypertension status. Conclusions: Longitudinally elevated SUA independently predicts the risk of new-onset CKD.
原文英語
頁(從 - 到)457-462
頁數6
期刊Journal of Nephrology
28
發行號4
DOIs
出版狀態已發佈 - 八月 23 2015

指紋

Uric Acid
Chronic Renal Insufficiency
Cohort Studies
Serum
Glomerular Filtration Rate
Body Mass Index
Confidence Intervals
Hypertension
Population

ASJC Scopus subject areas

  • Nephrology

引用此文

Elevated uric acid level as a significant predictor of chronic kidney disease : a cohort study with repeated measurements. / Chou, Yu Ching; Kuan, Jen Chun; Yang, Tsan; Chou, Wan Yun; Hsieh, Po Chien; Bai, Chyi-Huey; You, San Lin; Chen, Chien Hua; Wei, Cheng Yu; Sun, Chien An.

於: Journal of Nephrology, 卷 28, 編號 4, 23.08.2015, p. 457-462.

研究成果: 雜誌貢獻文章

Chou, YC, Kuan, JC, Yang, T, Chou, WY, Hsieh, PC, Bai, C-H, You, SL, Chen, CH, Wei, CY & Sun, CA 2015, 'Elevated uric acid level as a significant predictor of chronic kidney disease: a cohort study with repeated measurements', Journal of Nephrology, 卷 28, 編號 4, 頁 457-462. https://doi.org/10.1007/s40620-014-0158-9
Chou, Yu Ching ; Kuan, Jen Chun ; Yang, Tsan ; Chou, Wan Yun ; Hsieh, Po Chien ; Bai, Chyi-Huey ; You, San Lin ; Chen, Chien Hua ; Wei, Cheng Yu ; Sun, Chien An. / Elevated uric acid level as a significant predictor of chronic kidney disease : a cohort study with repeated measurements. 於: Journal of Nephrology. 2015 ; 卷 28, 編號 4. 頁 457-462.
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abstract = "Background: Cohort studies evaluating increased serum uric acid (SUA) level as a chronic kidney disease (CKD) risk factor have yielded variable results. We aimed to assess the association between the pattern of longitudinal changes in SUA and incident CKD [estimated glomerular filtration rate (eGFR) 2]. Methods: A population-based cohort study was conducted on 3,605 participants who were followed prospectively for a mean of 5.18 years. The longitudinal changes in SUA were categorized into three subgroups: persistently low, fluctuated (reduced or elevated), and persistently high. The primary outcome of interest was the development of CKD at a follow-up examination. Cox proportional hazards analysis was used to test the hypothesis. Results: After adjustment for potential confounders, participants with fluctuated SUA with progressively elevated level and persistently high SUA level had significantly higher risk of developing CKD compared to subjects with persistently low SUA level: adjusted hazard ratio (95 {\%} confidence interval) was 2.05 (1.24–3.38) vs. 1.90 (1.34–2.71). This longitudinal relationship was independent of sex, age, body mass index, and hypertension status. Conclusions: Longitudinally elevated SUA independently predicts the risk of new-onset CKD.",
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AB - Background: Cohort studies evaluating increased serum uric acid (SUA) level as a chronic kidney disease (CKD) risk factor have yielded variable results. We aimed to assess the association between the pattern of longitudinal changes in SUA and incident CKD [estimated glomerular filtration rate (eGFR) 2]. Methods: A population-based cohort study was conducted on 3,605 participants who were followed prospectively for a mean of 5.18 years. The longitudinal changes in SUA were categorized into three subgroups: persistently low, fluctuated (reduced or elevated), and persistently high. The primary outcome of interest was the development of CKD at a follow-up examination. Cox proportional hazards analysis was used to test the hypothesis. Results: After adjustment for potential confounders, participants with fluctuated SUA with progressively elevated level and persistently high SUA level had significantly higher risk of developing CKD compared to subjects with persistently low SUA level: adjusted hazard ratio (95 % confidence interval) was 2.05 (1.24–3.38) vs. 1.90 (1.34–2.71). This longitudinal relationship was independent of sex, age, body mass index, and hypertension status. Conclusions: Longitudinally elevated SUA independently predicts the risk of new-onset CKD.

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