Elevated serum osteoprotegerin may predict peripheral arterial disease after kidney transplantation: A single-center prospective cross-sectional study in Taiwan

Yen Cheng Chen, Bang Gee Hsu, Ching Chun Ho, Chung Jen Lee, Ming Che Lee

研究成果: 雜誌貢獻文章同行評審

4 引文 斯高帕斯(Scopus)

摘要

Background. Osteoprotegerin (OPG) is a potential biomarker for severity and complications of cardiovascular diseases. Peripheral arterial disease (PAD) is associated with an increased risk of death in kidney transplantation (KT) patients. This prospective cross-sectional study evaluated the relationship between serum OPG and PAD in KT patients. Methods. Seventy-four KT patients were enrolled for this PAD study. Fasting blood samples were obtained to measure serum OPG levels by using enzyme-linked im- munosorbent assay kits. The ankle-brachial index (ABI) of less than 0.9 was applied for PAD diagnosis. Results. Thirteen patients (17.6%) were diagnosed with PAD. Diabetes (P D 0:025), smoking (P D 0:010), and increased OPG levels (P D 0:001) were significantly more frequent in the PAD group. Multivariate logistic regression analysis showed that serum OPG (odds ratio [OR], 1.336; 95% CI [1.108-1.611]; P D 0:002) and diabetes (OR, 7.120; 95% CI [1.080-46.940]; P D0:041) were independent predictors of PAD in KT patients. The area under the receiver operating characteristic (ROC) curve determined that the probability of a serum OPG level of 7.117 pg/L in predicting PAD in KT patients was 0.799 (95% CI [0.690-0.884]; P <0:001). Discussion. Exploration of reliable biomarkers for early identification of vascular risk is crucial for KT patients. Elevated serum OPG levels may predict PAD in KT patients with cutoff value of 7.117 pg/L.

原文英語
文章編號e3847
期刊PeerJ
2017
發行號10
DOIs
出版狀態已發佈 - 2017
對外發佈

ASJC Scopus subject areas

  • 神經科學 (全部)
  • 生物化學、遺傳與分子生物學 (全部)
  • 農業與生物科學 (全部)

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