TY - JOUR
T1 - Elevated erythrocyte carbonic anhydrase activity is a novel clinical marker in hyperventilation syndrome
AU - Teng, Ying Hock
AU - Tsai, Hsiu Ting
AU - Hsieh, Yih Shou
AU - Chen, Yi Chen
AU - Lin, Chiao Wen
AU - Lee, Meng Chih
AU - Lin, Long Yau
AU - Yang, Shun Fa
PY - 2009/4/1
Y1 - 2009/4/1
N2 - Background: The aim of this study was to evaluate the erythrocyte carbonic anhydrase (CA) activity in patients with hyperventilation syndrome. Methods: A total of 71 patients with hyperventilation syndrome and 60 controls were recruited in this study for measurement of the erythrocyte CA activity. CA activity was analyzed from erythrocyte using CA esterase activity analysis. Results: The erythrocyte CA activity was significantly elevated in the patients with hyperventilation syndrome compared to controls (31.07±1.37 U/g Hb vs. 24.67±0.99 U/g Hb, p=0.003). The standardized β value and significant R2 value of total CA activity for prediction of hyperventilation was 0.155 (p=0.016) and 0.024, respectively. Moreover, a significant negative correlation was found between total CA activity and partial pressure of carbon dioxide (PaCO2) (r=-0.185, p=0.03, n=131). Furthermore, the adjusted odds ratios for patients with hyperventilation were 11.6 (95% CI: 4.8-27.9) and 51.0 (95% CI: 5.8-445.2) for individuals with either PaCO2≤28.1 mm Hg or CA activity ≥29.71 U/g hemoglobin (Hb), and for individuals with both PaCO2≤28.1 mm Hg and CA activity ≥29.71 U/g Hb, respectively, compared to individuals with both PaCO 2>28.1 mm Hg and CA activity <29.71 U/g Hb. Conclusions: Erythrocyte CA activity was significantly elevated in patients with hyperventilation. Detection of erythrocyte CA activity may provide a potential explanatory parameter for the prediction of hyperventilation syndrome.
AB - Background: The aim of this study was to evaluate the erythrocyte carbonic anhydrase (CA) activity in patients with hyperventilation syndrome. Methods: A total of 71 patients with hyperventilation syndrome and 60 controls were recruited in this study for measurement of the erythrocyte CA activity. CA activity was analyzed from erythrocyte using CA esterase activity analysis. Results: The erythrocyte CA activity was significantly elevated in the patients with hyperventilation syndrome compared to controls (31.07±1.37 U/g Hb vs. 24.67±0.99 U/g Hb, p=0.003). The standardized β value and significant R2 value of total CA activity for prediction of hyperventilation was 0.155 (p=0.016) and 0.024, respectively. Moreover, a significant negative correlation was found between total CA activity and partial pressure of carbon dioxide (PaCO2) (r=-0.185, p=0.03, n=131). Furthermore, the adjusted odds ratios for patients with hyperventilation were 11.6 (95% CI: 4.8-27.9) and 51.0 (95% CI: 5.8-445.2) for individuals with either PaCO2≤28.1 mm Hg or CA activity ≥29.71 U/g hemoglobin (Hb), and for individuals with both PaCO2≤28.1 mm Hg and CA activity ≥29.71 U/g Hb, respectively, compared to individuals with both PaCO 2>28.1 mm Hg and CA activity <29.71 U/g Hb. Conclusions: Erythrocyte CA activity was significantly elevated in patients with hyperventilation. Detection of erythrocyte CA activity may provide a potential explanatory parameter for the prediction of hyperventilation syndrome.
KW - Erythrocyte carbonic anhydrase activity
KW - Hyperventilation syndrome
UR - http://www.scopus.com/inward/record.url?scp=63849176059&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=63849176059&partnerID=8YFLogxK
U2 - 10.1515/CCLM.2009.102
DO - 10.1515/CCLM.2009.102
M3 - Article
C2 - 19327123
AN - SCOPUS:63849176059
VL - 47
SP - 441
EP - 445
JO - Zeitschrift fur klinische Chemie und klinische Biochemie
JF - Zeitschrift fur klinische Chemie und klinische Biochemie
SN - 1434-6621
IS - 4
ER -