Electrophysiological mapping and histological examinations of the swine atrium with sustained (≥24 h) atrial fibrillation: A suitable animal model for studying human atrial fibrillation

Jiunn Lee Lin, Ling Ping Lai, Chih Shen Lin, Chao Cheng Du, Tsu Juey Wu, Shih Ping Chen, Wen Chuan Lee, Ping Cheng Yang, Yung Zu Tseng, Wen Pin Lien, Shoei K.Stephen Huang

研究成果: 雜誌貢獻文章

19 引文 斯高帕斯(Scopus)

摘要

Objectives: Interventional elimination of chronic persistent atrial fibrillation (AFib) remains difficult. An animal model mimicking the clinical situation is important. Methods and Results: Twenty-five adult pigs were implanted with a high-speed atrial pacemaker. After continuous pacing at 600 bpm for 6 weeks, 20 (91%) of the 22 survivals developed sustained AFib lasting for at least 24 h. Epicardial dense mapping revealed multiple coexisting reentrant wavelets in the left and the right atrium (LA and RA, respectively; 10.6 ± 2.9 vs. 7.6 ± 2.4 wavelets/cm2/s; p < 0.002). The mean local A-A intervals were 87.2 ± 14.6 ms in the LA and 103.3 ± 19.0 ms in the RA (p < 0.0002). Acute termination of sustained AFib was successful in 3 of the 5 pigs by propafenone, but in none of the 6 by dl-sotalol. Epicardial cryothermal ablation failed to terminate any AFib by compartmentalization of the RA free wall alone (4 pigs) or together with the LA appendage (4 pigs). Electron microscopic examination demonstrated diffuse perinuclear myolysis, myofibrillar fragmentation and mitochondrial crystal disruption in the atrium. Conclusions: Pacing-induced sustained AFib (≥ 24 h) in adult pigs is a feasible and efficient animal model with electrophysiological and histological characteristics closely similar to those seen in humans.
原文英語
頁(從 - 到)78-84
頁數7
期刊Cardiology
99
發行號2
DOIs
出版狀態已發佈 - 五月 6 2003
對外發佈Yes

Keywords

  • Animal model
  • Antiarrhythmic drugs
  • Atrial compartmentalization
  • Atrial fibrillation
  • Electrophysiological mapping

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

指紋 深入研究「Electrophysiological mapping and histological examinations of the swine atrium with sustained (≥24 h) atrial fibrillation: A suitable animal model for studying human atrial fibrillation」主題。共同形成了獨特的指紋。

  • 引用此