Electropharmacologic characteristics of ventricular proarrhythmia induced by ibutilide

Yi Jen Chen, Ming Hsiung Hsieh, Chuen Wang Chiou, Shih Ann Chen

研究成果: 雜誌貢獻文章

26 引文 斯高帕斯(Scopus)

摘要

The purpose of this study was to evaluate in vivo the proarrhythmic effects of ibutilide in dogs with or without ventricular hypertrophy. Fourteen dogs received repeated experiments both during the acute and chronic phases (8 weeks, with ventricular hypertrophy) of complete atrioventricular (AV) block. Twelve-lead ECG, monophasic action potentials in the left and right ventricle were recorded before and after each dose of ibutilide (0.01- 0.08 mg/kg) during different ventricular rates. In these dogs, ibutilide increased QT interval, biventricular APD90, interventricular ΔAPD90 (difference between the left and right ventricular APD90), and QT dispersion, and induced early after depolarizations in a dose-dependent manner. The interventricular AAPD90, QT dispersion, and increases of QT interval were more pronounced during slower ventricular rates. There were greater QT interval, biventricular APD90, interventricular ΔAPD90, and QT dispersion values during chronic AV block than during acute AV block. Moreover, ibutilide can induce higher incidences of early afterdepolarizations and torsades de pointes [six (43%) of 14 versus 0 of 14; p <0.05] during chronic AV block than during acute AV block. In conclusion, ibutilide can prolong ventricular repolarization and increase dispersion of ventricular repolarization in a dose-dependent and reverse rate-dependent manner. The high incidence of torsades de pointes in the dogs during chronic AV block suggests the importance of ventricular hypertrophy in the occurrence of ibutilide-induced proarrhythmia.

原文英語
頁(從 - 到)237-247
頁數11
期刊Journal of Cardiovascular Pharmacology
34
發行號2
DOIs
出版狀態已發佈 - 八月 1999

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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