Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor

Chih Sheng Chu; Yu Chen Wang; Long Sheng Lu; Brian Walton; H. Ramazan Yilmaz; Roger Y. Huang; Tatsuya Sawamura; Richard A F Dixon; Wen Ter Lai; Chu Huang Chen; Jonathan Lu

doi:10.1371/journal.pone.0070533

Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor

Chih Sheng Chu, Yu Chen Wang, Long Sheng Lu, Brian Walton, H. Ramazan Yilmaz, Roger Y. Huang, Tatsuya Sawamura, Richard A F Dixon, Wen Ter Lai, Chu Huang Chen, Jonathan Lu

研究成果: 雜誌貢獻 › 文章 › 同行評審

34 引文斯高帕斯（Scopus）

摘要

Objectives:Increased plasma C-reactive protein (CRP) levels are associated with the occurrence and severity of acute coronary syndrome. We investigated whether CRP can be generated in vascular endothelial cells (ECs) after exposure to the most electronegative subfraction of low-density lipoprotein (LDL), L5, which is atherogenic to ECs. Because L5 and CRP are both ligands for the lectin-like oxidized LDL receptor-1 (LOX-1), we also examined the role of LOX-1.Methods and Results:Plasma LDL samples isolated from asymptomatic hypercholesterolemic (LDL cholesterol [LDL-C] levels, 154.6±20 mg/dL; n = 7) patients and normocholesterolemic (LDL-C levels, 86.1±21 mg/dL; P

原文	英語
文章編號	e70533
期刊	PLoS One
卷	8
發行號	8
DOIs	https://doi.org/10.1371/journal.pone.0070533
出版狀態	已發佈 - 八月 8 2013
對外發佈	Yes

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

存取文件

10.1371/journal.pone.0070533

其它文件與鏈接

指紋深入研究「Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor」主題。共同形成了獨特的指紋。

引用此

Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor. / Chu, Chih Sheng; Wang, Yu Chen; Lu, Long Sheng; Walton, Brian; Yilmaz, H. Ramazan; Huang, Roger Y.; Sawamura, Tatsuya; Dixon, Richard A F; Lai, Wen Ter; Chen, Chu Huang; Lu, Jonathan.

於: PLoS One, 卷 8, 編號 8, e70533, 08.08.2013.

研究成果: 雜誌貢獻 › 文章 › 同行評審

Chu, Chih Sheng ; Wang, Yu Chen ; Lu, Long Sheng ; Walton, Brian ; Yilmaz, H. Ramazan ; Huang, Roger Y. ; Sawamura, Tatsuya ; Dixon, Richard A F ; Lai, Wen Ter ; Chen, Chu Huang ; Lu, Jonathan. / Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor. 於: PLoS One. 2013 ; 卷 8, 編號 8.

@article{02fea269265c40e3ae2c2b6aafbb3c65,

title = "Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor",

abstract = "Objectives:Increased plasma C-reactive protein (CRP) levels are associated with the occurrence and severity of acute coronary syndrome. We investigated whether CRP can be generated in vascular endothelial cells (ECs) after exposure to the most electronegative subfraction of low-density lipoprotein (LDL), L5, which is atherogenic to ECs. Because L5 and CRP are both ligands for the lectin-like oxidized LDL receptor-1 (LOX-1), we also examined the role of LOX-1.Methods and Results:Plasma LDL samples isolated from asymptomatic hypercholesterolemic (LDL cholesterol [LDL-C] levels, 154.6±20 mg/dL; n = 7) patients and normocholesterolemic (LDL-C levels, 86.1±21 mg/dL; P",

author = "Chu, {Chih Sheng} and Wang, {Yu Chen} and Lu, {Long Sheng} and Brian Walton and Yilmaz, {H. Ramazan} and Huang, {Roger Y.} and Tatsuya Sawamura and Dixon, {Richard A F} and Lai, {Wen Ter} and Chen, {Chu Huang} and Jonathan Lu",

year = "2013",

month = aug,

day = "8",

doi = "10.1371/journal.pone.0070533",

language = "English",

volume = "8",

journal = "PLoS One",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "8",

}

TY - JOUR

T1 - Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor

AU - Chu, Chih Sheng

AU - Wang, Yu Chen

AU - Lu, Long Sheng

AU - Walton, Brian

AU - Yilmaz, H. Ramazan

AU - Huang, Roger Y.

AU - Sawamura, Tatsuya

AU - Dixon, Richard A F

AU - Lai, Wen Ter

AU - Chen, Chu Huang

AU - Lu, Jonathan

PY - 2013/8/8

Y1 - 2013/8/8

N2 - Objectives:Increased plasma C-reactive protein (CRP) levels are associated with the occurrence and severity of acute coronary syndrome. We investigated whether CRP can be generated in vascular endothelial cells (ECs) after exposure to the most electronegative subfraction of low-density lipoprotein (LDL), L5, which is atherogenic to ECs. Because L5 and CRP are both ligands for the lectin-like oxidized LDL receptor-1 (LOX-1), we also examined the role of LOX-1.Methods and Results:Plasma LDL samples isolated from asymptomatic hypercholesterolemic (LDL cholesterol [LDL-C] levels, 154.6±20 mg/dL; n = 7) patients and normocholesterolemic (LDL-C levels, 86.1±21 mg/dL; P

AB - Objectives:Increased plasma C-reactive protein (CRP) levels are associated with the occurrence and severity of acute coronary syndrome. We investigated whether CRP can be generated in vascular endothelial cells (ECs) after exposure to the most electronegative subfraction of low-density lipoprotein (LDL), L5, which is atherogenic to ECs. Because L5 and CRP are both ligands for the lectin-like oxidized LDL receptor-1 (LOX-1), we also examined the role of LOX-1.Methods and Results:Plasma LDL samples isolated from asymptomatic hypercholesterolemic (LDL cholesterol [LDL-C] levels, 154.6±20 mg/dL; n = 7) patients and normocholesterolemic (LDL-C levels, 86.1±21 mg/dL; P

UR - http://www.scopus.com/inward/record.url?scp=84881345898&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881345898&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0070533

DO - 10.1371/journal.pone.0070533

M3 - Article

C2 - 23950953

AN - SCOPUS:84881345898

VL - 8

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 8

M1 - e70533

ER -