摘要
Objectives:Increased plasma C-reactive protein (CRP) levels are associated with the occurrence and severity of acute coronary syndrome. We investigated whether CRP can be generated in vascular endothelial cells (ECs) after exposure to the most electronegative subfraction of low-density lipoprotein (LDL), L5, which is atherogenic to ECs. Because L5 and CRP are both ligands for the lectin-like oxidized LDL receptor-1 (LOX-1), we also examined the role of LOX-1.Methods and Results:Plasma LDL samples isolated from asymptomatic hypercholesterolemic (LDL cholesterol [LDL-C] levels, 154.6±20 mg/dL; n = 7) patients and normocholesterolemic (LDL-C levels, 86.1±21 mg/dL; P
原文 | 英語 |
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文章編號 | e70533 |
期刊 | PLoS One |
卷 | 8 |
發行號 | 8 |
DOIs | |
出版狀態 | 已發佈 - 8月 8 2013 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 農業與生物科學 (全部)
- 生物化學、遺傳與分子生物學 (全部)
- 醫藥 (全部)