摘要
Aim: Development of epigallocatechin gallate (EGCG) and gelatin-doxorubicin conjugate (GLT-DOX)-coated gold nanoparticles (DOX-GLT/EGCG AuNPs) for fluorescence imaging and inhibition of prostate cancer cell growth. Materials & methods: AuNPs alternatively coated with EGCG and DOX-GLT conjugates were prepared by a layer-by-layer assembly method. The physicochemical properties of the AuNPs and the effect of Laminin 67R receptor-mediated endocytosis on the anticancer efficacy of the AuNPs were examined. Results: The AuNPs significantly inhibit the proliferation of PC-3 cancer cell and the enzyme-responsive intracellular release of DOX could be tracked by monitoring the recovery of the fluorescence signal of DOX. Conclusion: Laminin 67R receptor-mediated delivery of DOX using the AuNPs enhanced cellular uptake of DOX and improved apoptosis of PC-3 cells.
原文 | 英語 |
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頁(從 - 到) | 9-30 |
頁數 | 22 |
期刊 | Nanomedicine |
卷 | 11 |
發行號 | 1 |
DOIs | |
出版狀態 | 已發佈 - 1月 1 2016 |
ASJC Scopus subject areas
- 材料科學(全部)
- 生物工程
- 生物醫學工程
- 醫藥(雜項)
- 發展